Active Cocaine Users Clinical Trial
Official title:
Impact of Sustained Release d-Amphetamine on Choice Between Cocaine and a Non-Drug Reinforcer
| Verified date | March 2019 |
| Source | University of Kentucky |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Interventional |
Cocaine-use disorders continue to be a significant public health concern, yet no effective medications have been identified. The goal of this study is to establish a research platform for the development of medications for treatment of cocaine abuse and dependence. This study will incorporate choice self-administration procedures between drug and a non-drug alternative reinforcer presented during maintenance on d-amphetamine, which has been previously shown to reduce cocaine use.
| Status | Completed |
| Enrollment | 18 |
| Est. completion date | April 5, 2018 |
| Est. primary completion date | April 5, 2018 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 21 Years to 45 Years |
| Eligibility |
Inclusion Criteria: - Recent cocaine use, otherwise healthy Exclusion Criteria: - Laboratory results outside of clinically acceptable ranges, history of or current serious physical or psychiatric disease |
| Country | Name | City | State |
|---|---|---|---|
| United States | Laboratory of Human Behavioral Pharmacology | Lexington | Kentucky |
| Lead Sponsor | Collaborator |
|---|---|
| Joshua A. Lile, Ph.D. |
United States,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative | The reinforcing effects of cocaine were determined using a modified progressive ratio procedure (Lile et al., 2016) in which subjects made 9 choices between each available cocaine dose and money (US$6.00). Reinforcing effects are measured for each cocaine dose during both d-amphetamine and placebo maintenance. | 9 choice trials per cocaine dose level with each trial separated by 30 minutes |