Gene & Protein Expression Profiles After Treatment of Actinic Keratoses

Clinical Trial Summary

The primary aim of this study is to investigate the effect of 5-fluorouracil, imiquimod, and melatonin for actinic keratosis on immunological gene, and protein expressions profiles. Secondarily, the aim is to assess the effect of the treatment on the histopathology of actinic keratoses.

See also
Status	Clinical Trial	Phase
Completed	`NCT03575780` - Single-Center Study Evaluating Systemic Exposure and Safety of KX2-391 Ointment 1% on the Face or Balding Scalp in Subjects With Actinic Keratosis	Phase 1
Completed	`NCT04085367` - Multicenter Study to Assess the Efficacy and Safety of Methyl Aminolevulinate Hydrochloride (MAL) 16.8% Cream (CD06809-41) Versus Vehicle Cream for Actinic Keratosis of the Face	Phase 3
Completed	`NCT05937529` - Impact of Madecassoside and 5 % Panthenol Cream in Post Photodynamic Therapy for Actinic Keratosis	N/A
Completed	`NCT02520700` - A Comparison of White-light and Daylight Topical Methyl 5-aminolaevulinic Acid Photodynamic Therapy for Actinic Keratoses	N/A
Terminated	`NCT01538901` - Imiquimod Versus Photodynamic Therapy of Actinic Keratoses in Organ Transplant Recipients	Phase 4
Completed	`NCT01354717` - Bioequivalence Study of Generic Fluorouracil 0.5% Cream and 0.5% Carac® and Placebo	Phase 3
Completed	`NCT00742391` - A Multicenter Study to Evaluate the Efficacy and Safety of PEP005 (Ingenol Mebutate) Gel When Used to Treat Actinic Keratoses (AKs) on the Non Head Locations	Phase 3
Completed	`NCT03285477` - A Multi-Center Study to Evaluate the Efficacy and Safety of KX2-391 Ointment 1% on AK on Face or Scalp	Phase 3
Suspended	`NCT03963102` - Duration of Ameluz Application in Acral Actinic Keratoses Response	Phase 4
Not yet recruiting	`NCT05923060` - Imaging Techniques to Monitor Photosensitizer and sO2 Levels During Photodynamic Therapy of Actinic Keratoses	Phase 2
Withdrawn	`NCT06026358` - Tirbanibulin 1% Ointment for the Treatment of Actinic Keratosis on the Back of the Hands	Phase 4
Completed	`NCT02622594` - Bilateral Comparison of Treatment of Facial Actinic Keratoses Using Microneedling and Photodynamic Therapy With Aminolevulinic Acid and Blue Light Versus Photodynamic Therapy With Aminolevulinic Acid and Blue Light Using Two Incubation Times	Phase 4
Completed	`NCT00786994` - The Efficacy and Tolerability of Oleogel-S-10 in Patients With Actinic Keratoses	Phase 2
Completed	`NCT00774787` - Topical Imiquimod Cream in Combination With Cryotherapy for the Treatment of Actinic Keratoses	Phase 4
Completed	`NCT00544258` - Pharmacokinetic Study to Evaluate the Extent of Systemic Absorption of PEP005	Phase 1
Completed	`NCT04024579` - Treatment of Actinic Keratosis With 5% KOH Solution
Completed	`NCT04843553` - Nicotinamide for Prevention of Pre-malignant Actinic Keratosis in Kidney Transplant Recipients	Early Phase 1
Completed	`NCT03315286` - Validation of SHADE a Mobile Technology for Monitoring of Ultraviolet Exposure	N/A
Completed	`NCT03279328` - Evaluating Skin Appearance Following 5-Flourouracil Cream for Treatment of Actinic Keratosis and the Effects of Topical Agents	Phase 4
Completed	`NCT02062853` - Continuous Quality Improvement (CQI) Pilot Study Evaluating the Utility of an Educational Video	N/A

NCT number	NCT05740969
Study type	Interventional
Source	Zealand University Hospital
Contact	Jawad A Zahid, MD
Phone	+4551329815
Email	jaza@regsj.dk
Status	Recruiting
Phase	Phase 2
Start date	February 1, 2023
Completion date	December 31, 2024

Gene and Protein Expression Profiles After Treatment of Actinic Keratoses — PACKS

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms