Topical Application of Imiquimod Gel at Different Concentrations in Actinic Cheilitis

Actinic Cheilitis Clinical Trial

Official title:
Evaluation of Topical Application of 5% Imiquimod, 0.05% Imiquimod and 0.05% Nanoencapsulated Imiquimod Gel in the Treatment of Actinic Cheilitis: a Randomized Controlled Trial

Status Terminated

Clinical Trial Summary

Actinic cheilitis is a potentially malignant lesion on the lower lip, which can progress to more serious illnesses such as cancer if not treated. Usually treatment of this condition is only based on clinical appearance, but there is no established cure treatment. Topical imiquimod is a medicine indicated for the treatment of skin diseases, but it has not yet been proven to treat actinic cheilitis. In this research, the investigator's aim is to evaluate the response to actinic cheilitis treatment with the current standard treatment compared to high and low concentration imiquimod topical formulations.

Clinical Trial Description

Three formulations are used in this research: imiquimod 5%, imiquimod 0.05% e imiquimod nanoencapsulated 0.05%. Nanoencapsulation is a process that concentrates the drug into a capsule not visible to the naked eye, allowing it to penetrate skin more easily and will only release the drug at the lesion site. The drug is presented in a free form inside the gel in the others formulations. ;

Study Design

Related Conditions & MeSH terms

Actinic Cheilitis

Clinical Trial Details

NCT number	NCT04219358
Study type	Interventional
Source	Hospital de Clinicas de Porto Alegre
Contact
Status	Terminated
Phase	Phase 1
Start date	March 23, 2019
Completion date	August 24, 2021

View Details

See also
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Not yet recruiting	`NCT03990636` - Photodynamic Therapy With Metil 5-aminolevulinate for Actinic Cheilitis - Phase 2 Clinical Trial	Phase 2
Completed	`NCT00849992` - Treatment Study for Actinic Cheilitis Comparing Imiquimod 5% and Photodynamic Therapy	Phase 4
Recruiting	`NCT06321003` - SYsteMatical Trained learnIng aLgorithms for Oral carcInogenesiS Interpretation by Optical Coherence Tomography
Recruiting	`NCT04744103` - Trichloroacetic Acid as a Topical Treatment for Actinic Cheilitis	Phase 4
Completed	`NCT00868088` - Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the Lip	Phase 4
Completed	`NCT02198469` - Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Actinic Cheilitis	Phase 1
Withdrawn	`NCT03452566` - Evaluation of Ingenol Mebutate for Actinic Cheilitis Treatment	Phase 1/Phase 2
Completed	`NCT02409732` - Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic Cheilitis	Phase 4