Haploidentical Stem Cell Transplantation for Children With Acquired Severe Aplastic Anemia

Acquired Aplastic Anemia Clinical Trial

Official title:
Haploidentical Stem Cell Transplantation With Fixed Dose of T Cells After in Vitro T Cell Depletion Using CD3 Monoclonal Antibody for Children With Acquired Severe Aplastic Anemia

Status Recruiting

Clinical Trial Summary

Rationale: Fludarabine, cyclophosphamide, anti-thymocyte globulin and low-dose total body irradiation (LD-TBI) may induce the engraftment cross the immunologic barrier in the setting of HLA-haploidentical allogeneic hematopoietic cell transplantation. In addition, depletion of CD3 cells may contribute to prevent developing severe acute graft versus host disease (GVHD) in haploidentical transplantation.

Purpose: Phase II trials to evaluate the efficacy of haploidentical stem cell transplantation with fixed dose of T cells after in vitro T cell depletion using CD3 monoclonal antibody for children with acquired severe aplastic anemia

Clinical Trial Description

n/a

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01759732
Study type	Interventional
Source	Asan Medical Center
Contact	Ho Joon Im, MD, PhD
Phone	82-2-3010-3371
Email	hojim@amc.seoul.kr
Status	Recruiting
Phase	Phase 2
Start date	September 2012
Completion date	December 2015

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT01343953` - Cord Blood Transplantation in Severe Aplastic Anemia	Phase 2
Active, not recruiting	`NCT03904134` - Clinical Transplant-Related Long-term Outcomes of Alternative Donor Allogeneic Transplantation (BMT CTN 1702)	N/A
Recruiting	`NCT03047746` - Unrelated And Partially Matched Related Donor PSCT w/ T Cell Receptor (TCR) αβ Depletion for Patients With BMF	N/A
Recruiting	`NCT03413306` - Eltrombopag+hATG+CsA vs. hATG+CsA in Children With Severe AA	Phase 3