Acoustic Neuroma Clinical Trial
Official title:
Kan tumorvækst Forudsiges Ved RGD-PET/MR af Vestibularis Schwannomer?
The aim of this non-randomised, prospective study is to investigate the applicability and prognostic value of angiogenesis PET/MR with the radioligand 68Ga-NODAGA- E[c(RGDyK)]2 in patients with sporadic Vestibuarl Schwannomas.
The radioligand 68Ga-NODAGA- E[c(RGDyK)]2 targets the Arg-Gly-Asp (RGD) sequence known to
bind with the αvβ3 integrin that is expressed on the surface of angiogenic blood vessels or
tumor cells. The radioligand can be used to visualize tumor angiogenesis using PET/MR.
A total of 40 patients diagnosed with sporadic vestibular schwannomas will be subjected to an
angiogenesis-PET/MR scan. Follow-up MR-only scan will be performed (from the time of the
angiogenesis PET/MR) minimum 2 months later in regards to calculate growth rate. The uptake
of 68Ga-NODAGA-E[c(RGDyK)]2 (Standardized Uptake Values, SUVmax) in tumor lesions will be
quantified as Standardized Uptake Values (SUVmax/SUVmean) and compared with PFS, DSS and OS
(dichotomized above/below median SUVmax and analyzed by Kaplan-Meier).
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