The Lipid Profile of the Skin Surface in Acne

Acne Clinical Trial

— Acne  

Official title:

The Lipid Profile of the Skin Surface in Acne

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02180425
• Other study ID #: 531506
• Status: Completed
• Phase: N/A
• First received: June 30, 2014
• Last updated: May 25, 2017
• Start date: November 2013
• Est. completion date: July 2015

Study information

• Verified date: May 2017
• Source: University of California, Davis
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to evaluate the differences in the skin lipid profile of patients with and without acne. Secondly, the goal is to learn more about what the effects of retinoinds (topical and systemic) are on the the skin lipid profile. We hypothesize that the skin lipid profile of subjects with acne will be lower in inflammatory lipids in comparison to subjects without acne.

Description:

Skin lipid profile will be conducted via sebutapes- adhesive tapes that painlessly absorbs sebum from the face. These tapes will be placed on the face for 1 hour. A photograph of the face will be taken during each study visit. A sebumeter will also be used to measure skin sebum secretion rate.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: July 2015
• Est. primary completion date: May 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 12 Years to 30 Years

Eligibility

Inclusion Criteria:

• age 12 to 30 years

• have been prescribed tretinoin OR isotretinoin

Exclusion Criteria:

• those who have taken isotretinoin (systemic)

• those who used tretinoin or other topical retinoid within two weeks of starting the study

• those with seborrheic dermatitis, rosacea, or polycystic ovary syndrome

• those who are pregnant, prisoners, or cognitively impaired

• those who do not fit the inclusion criteria

Related Conditions & MeSH terms

• Acne

Intervention

Drug:
• Tretinoin or Adapalene
Subjects will apply a pea sized amount of topical retinoid cream once daily at night for 30 days. Subjects will return for a follow-up visit.
• Isotretinoin
Subjects will take one pill once daily for 5 months. Subjects will return after 1 month and after 4-5 months of treatment for skin lipid profiling.

Locations

Country	Name	City	State
United States	Dermatology Research Area	Davis	California
United States	UC Davis Department of Dermatology	Sacramento	California

Sponsors (1)

Lead Sponsor	Collaborator
University of California, Davis

Country where clinical trial is conducted

United States, 

References & Publications (5)

Blume U, Verschoore M, Poncet M, Czernielewski J, Orfanos CE, Schaefer H. The vellus hair follicle in acne: hair growth and sebum excretion. Br J Dermatol. 1993 Jul;129(1):23-7. — View Citation

Doshi A, Zaheer A, Stiller MJ. A comparison of current acne grading systems and proposal of a novel system. Int J Dermatol. 1997 Jun;36(6):416-8. — View Citation

Morello AM, Downing DT, Strauss JS. Octadecadienoic acids in the skin surface lipids of acne patients and normal subjects. J Invest Dermatol. 1976 May;66(5):319-23. — View Citation

Thody AJ, Shuster S. Control and function of sebaceous glands. Physiol Rev. 1989 Apr;69(2):383-416. Review. — View Citation

Zouboulis CC, Baron JM, Böhm M, Kippenberger S, Kurzen H, Reichrath J, Thielitz A. Frontiers in sebaceous gland biology and pathology. Exp Dermatol. 2008 Jun;17(6):542-51. doi: 10.1111/j.1600-0625.2008.00725.x. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Skin lipid profile of acne and healthy patients	Compare the skin lipid profile of acne and healthy patients at baseline	baseline visit
Secondary	Skin lipid profile of acne patients after treatment	Patients in the topical retinoid group will have their lipids evaluated after 1 month of treatment. Patients in the systemic retinoid (isotretinoin) group will have their lipids evaluated after 1 and 4-5 months of treatment.	at 1 month and 4-5 months of treatment

External Links

•   University of California-Davis Department of Dermatology Clinical Research