Acne Clinical Trial
Official title:
An Evaluator-blind, Randomized, Vehicle-controlled Efficiency of Adjunctive Usage of a Moisturizer Containing Licochalcone A, L-carnitine and 1,2-decanediol With Adapalene Gel for Improvement of Local Tolerance in Thai Acne Subjects
Acne is an inflammation of sebaceous glands and follicles. Applying topical treatments such
as adapalene gel may cause irritant adverse effects. Hence, using a moisturizer is another
way to protect or relieve this undesirable event. Moisturizers that have anti-inflammatory
property could reduce irritant effects, emergent from using topical treatment and also
reduce severity of acne.
Research teams chose an adapalene gel to act as topical treatment for curing acne. It has
anti-inflammatory and comedolytic effects and has fewer side effects than other groups of
topical retinoic acids. However, peeling skin, redness skin, tingling sensation or itching
sensation may occur if they are continually used for a long period. Thus, for the purpose of
studying the efficacy of moisturizer containing licochalcone A, L-carnitine and
1,2-decanediol in reducing irritant effect of using adapalene gel (Licochalcone A has
anti-inflammatory effect, L-carnitine decrease sebum production and 1,2-decanediol has
anti-bacterial effect).
The investigators team research with patients by separate patients into 3 groups and compare among each other. In the first group use only adapalene gel, the second group use adapalene gel with moisturizer containing three substances mentioned above, and the last group use adapalene gel with placebo moisturizer. To compare outcomes among 3 groups, the investigators will measure degree of redness, scale, oily face, moist, number of acne, quality of life, and satisfaction after using moisturizer. ;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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