Acne Vulgaris Clinical Trial
Official title:
Comparison of Malassezia Spp Proportions in Inflammatory and Non Inflammatory Facial Acne Vulgaris Lesions
Acne vulgaris (AV) is a common inflammatory condition involving pilosebaceous unit. The
pathogenesis of acne is multifactorial and skin microbiome is considered to be one of the key
factors that aggravate inflammation. Malassezia spp is normal flora on the skin and several
studies have reported its corelation with inflammatory AV lesion.
Malassezia have higher lipase activity compared to Propionibacterium acnes which triggers an
increase in free fatty acid and glycerol, the chemotactic factors towards neutrophils and
inducing inflammation in AV. Malassezia folliculitis (MF) is sometimes confused with and may
present together with AV. Pruritus usually presents in MF but some studies also reported
itching as common symptom in AV.
The objectives of this study were to identify the presence and the distribution of Malassezia
spp. in facial AV lesions, to compare the distribution of Malassezia spp. between
inflammatory and non-inflammatory lesions and to identify the association between Malassezia
spp in acne lesions and pruritus symptom.
This study used cross sectional design study.
Subjects with eligible criteria were included. Subjects were divided into subjects with
inflammatory lesions and subjects with non inflammatory lesions.
Physical examination consisted of assesment of AV severity (using Lehman criteria) and
presence of pruritus based on visual analog scale. Clinical documetations were taken.
Follicular content of four inflammatory lesions or four non inflammatory lesions were
collected for microscopic examination with KOH solution and fungal culture examination (using
CHROMagar Malassezia, Dextrose Saboraud agar (DSA), and Tween 60-esculin agar).
The presence of Malassezia spp and its spore load in both groups were assesed and analyzed
for its corelation with AV severity and presence of pruritus.
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