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NCT04224597 Clinical Trial

Evaluation of the Presence of Enthesitis in Patients With Acne Vulgaris

Acne Vulgaris Clinical Trial

Official title:
Evaluation of the Presence of Enthesitis in Patients With Acne Vulgaris

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT04224597
Other study ID # Hitit University
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date February 1, 2020
Est. completion date April 1, 2020

Study information
Verified date January 2020
Source Erol Olcok Corum Training and Research Hospital
Contact Dilek E Büyüksireci
Phone +905439196253
Email dilekeker55@gmail.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Acne vulgaris is an inflammatory disease of the pilosebaceous unit, affecting about 85% of the young population. In the studies p. acne is a potent stimulator of the release of IFN-gamma (IFN-)) and IL-17 from CD4 + T cells, and the presence of IL-17 + cells in the perifollicular infiltrate has been shown in biopsies of inflammatory acne lesions. Therefore, acne is thought to be a Th17-related disease (1).

This study was aimed to evaluate the presence of enthesitis in patients with acne vulgaris.

Description:

Patients with acne vulgaris and healthy controls aged between 18-25 who admitted to Hitit University Erol Olcok Education and Research Hostpital Dermatology policlinic will be icluded. Patients with rheumatic, neurological diseases, history of trauma and previous fractures will be excluded from the study. After all the participants were evaluated by the dermatologist and demographic data will be recorded, the participants will be examined by the physical medicine and rehabilitation specialist and the short form-36 (sf-36), hospital anxiety and depression scale will be completed. Bilateral lower extremity tendon thicknesses and the presence of erosion, bursitis, etc. will be evaluated according to the criteria of Guess (Glasgow Ultrasound Enthesitis Scoring System) and Guess score will be determined for all participants. A total of 48 participants, 24 patients with acne vulgaris and 24 healthy controls, will be included in the study (2).

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 48
Est. completion date April 1, 2020
Est. primary completion date April 1, 2020
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group 18 Years to 25 Years
Eligibility Inclusion Criteira:

- Patients with acne vulgaris and healthy controls aged between 18-25

Exclusion Criteria:

- Participants with rheumatic and neurologic disease, history of trauma ,

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• ultrasonography
all participants will be determined by ultrasonography.

Locations
Country Name City State
Turkey Dilek Eker Büyüksireci Çorum Central Anatolia

Sponsors (1)
Lead Sponsor Collaborator
Erol Olcok Corum Training and Research Hospital

Country where clinical trial is conducted

Turkey, 

Outcome
Type Measure Description Time frame Safety issue
Primary patellar tendon thicknesses of patients with acne vulgaris and healthy controls 3 months
Primary Ashilles tendon thicknesses of patients with acne vulgaris and healthy controls 3 months
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