Effects of HMB Supplementation on Recovery Following ACL Surgery

Status Completed

Clinical Trial Summary

The anterior cruciate ligament (ACL) is a primary stabilizer of the knee, and thus when ACL injury occurs participation in physical activity is compromised. Reconstructive surgery is often necessary to repair the damage which is then followed by a regimen of physical therapy in order to regain full activity. Nutritional intervention after the surgery could help the patient maintain muscle mass during recovery, thus allowing for a quicker return to normal activity.

Clinical Trial Description

Beta-hydroxy-beta-methylbutyrate (HMB) is a nutritional supplement shown to improve muscle mass with exercise, and also in muscle loss conditions caused by a decrease in physical activity. Participants will be recruited who will undergo reconstructive surgery for a complete ACL tear and will then enter a standard physical therapy program during a six week recovery period. Subjects will receive either HMB or a placebo supplement during the recovery period. Muscle mass will be measured two weeks prior to the surgery and again after the recovery period using an InBody 720 body composition analyzer. Additionally, the Knee Injury and Osteoarthritis Outcome Score (KOOS) questionnaire will be administered as a measure of recovery and activity level during the study. ;

Study Design

Related Conditions & MeSH terms

ACL Injury
Anterior Cruciate Ligament Injuries

Clinical Trial Details

NCT number	NCT02602561
Study type	Interventional
Source	Metabolic Technologies Inc.
Contact
Status	Completed
Phase	N/A
Start date	November 2015
Completion date	August 2017

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04519801` - BFR Therapy for Post-Op Rehab of ACL Reconstruction With Quadriceps Tendon Autograft	N/A
Withdrawn	`NCT03389685` - Can PRP Reduce Pro-Inflammatory Biomarkers Following ACL Injury	Phase 2
Recruiting	`NCT04958733` - Does Bone Grafting at the Time of Bone-Patellar Tendon-Bone ACL Reconstruction Reduce the Incidence of Post-operative Anterior Knee Pain: A Randomized Controlled Clinical Study	N/A
Terminated	`NCT04101682` - Continuous Vs Single Shot Block After ACL	Early Phase 1
Not yet recruiting	`NCT05374382` - A Prehab Strengthening Program Prior to ACL Surgery on Lower Limb Structure and Function	N/A
Not yet recruiting	`NCT04068701` - Real-time Sensorimotor Feedback for Injury Prevention in Males Assessed in Virtual Reality	N/A
Recruiting	`NCT03479775` - Muscle Function and Traumatic Knee Injury in Sports
Not yet recruiting	`NCT05498285` - Post-ACL Reconstruction Rehab UPSCALER App RCT HPUPM	N/A
Recruiting	`NCT05461625` - ACL Reconstruction With/Without ALL Reconstruction	N/A
Active, not recruiting	`NCT03491046` - Molecular Imaging Assessment of ACL Viability	N/A
Withdrawn	`NCT04342000` - The Effect of Movement Education on Jumping/Landing Quality in High School Athletes	N/A
Completed	`NCT04993339` - Clinical Outcomes of ACL Reconstruction Augmented by an Injectable Osteoconductive/Osteoinductive Compound	Phase 3
Withdrawn	`NCT03614351` - Dietary Protein Intake and Rehabilitation From Anterior Cruciate Ligament Surgery	N/A
Withdrawn	`NCT03670550` - Dynamic ACL Brace: In Vivo Kinematics	N/A
Recruiting	`NCT06206200` - The Effect of Cognitive Dual-task Rehabilitation on Arthrogenic Muscle Responses After ACL Reconstruction	N/A
Active, not recruiting	`NCT06167343` - Comparison of Semitendinosus and Quadriceps Grafts for Anterior Cruciate Ligament Reconstruction	N/A
Completed	`NCT04541940` - TeleRehabilitation Following ACL Reconstruction	N/A
Terminated	`NCT03497780` - Longitudinal Assessment of Cartilage Injury and Remodeling After Anterior Cruciate Ligament Rupture and Reconstruction:
Completed	`NCT04967937` - Neuromuscular Training Improves Single-Limb Stability	N/A
Recruiting	`NCT04901858` - Knee Aspiration and High Definition MRI for ACL Injury	N/A