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Acidosis clinical trials

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NCT ID: NCT03846258 Withdrawn - Acute Kidney Injury Clinical Trials

High Versus Low Bicarbonate Bath in Critically-ill Patients Receiving Continuous Renal Replacement Therapy

Start date: May 1, 2019
Phase: Phase 4
Study type: Interventional

Researchers are trying to determine which dialysis solution, low bicarbonate fluid (22 mmol/L) or high bicarbonate fluid (32 mmol/L), is better in subjects with acute kidney injury (acute kidney failure) and metabolic acidosis that are admitted to the intensive care unit and require continuous renal replacement therapy (also known as continuous dialysis).

NCT ID: NCT03831152 Withdrawn - Clinical trials for Acidosis, Renal Tubular

Extension Study in Primary Distal Renal Tubular Acidosis

Start date: December 20, 2023
Phase: Phase 3
Study type: Interventional

Open-label study involving longitudinal assessment of the continued safety, tolerability, and efficacy of ADV7103 in maintaining targeted serum bicarbonate levels, preventing metabolic acidosis, and preventing hypokalemia in the following groups of subjects with primary dRTA: 1. subjects who participated in Study B23CS and were adherent to the protocol; 2. subjects ≥ 6 months of age who are living in Europe and did not participate in Study B23CS; and 3. infants younger than 6 months of age

NCT ID: NCT03723993 Withdrawn - Lactic Acidosis Clinical Trials

Remote Ischemic Preconditioning During Cardiopulmonary Bypass

RIPC
Start date: January 15, 2018
Phase: N/A
Study type: Interventional

The objective of study is to detect effect of remote ischemic preconditioning on serum lactate levels during and after cardiac surgery with cardiopulmonary bypass in addition to its effect on cardiac and renal clinical outcomes.

NCT ID: NCT03122678 Withdrawn - Septic Shock Clinical Trials

Thiamine Supplementation in Patients With Septic Shock

Start date: November 5, 2016
Phase: Phase 1
Study type: Interventional

To determine if intravenous thiamine would decrease the time to reversal of shock in patients with septic shock.

NCT ID: NCT01973504 Withdrawn - Trauma Clinical Trials

Phase 2c Dose Comparison Study of MP4OX in Trauma

Start date: December 2013
Phase: Phase 2
Study type: Interventional

MP4OX is being developed as an ischemic rescue therapy to perfuse and oxygenate tissues at risk during hemorrhagic shock. MP4OX is a pegylated hemoglobin-based colloid designed to improve perfusion and target delivery of oxygen to ischemic tissues. This study will evaluate safety and efficacy of MP4OX treatment, in addition to standard therapy, in trauma patients suffering from lactic acidosis due to severe hemorrhagic shock.

NCT ID: NCT01477476 Withdrawn - Type I Diabetes Clinical Trials

Anti-IL-1 Treatment in Children Diabetic Keto-Acidosis (DKA) at Diagnosis of Type 1 Diabetes

Start date: March 2012
Phase: Phase 2
Study type: Interventional

This is a randomized, double-blind, placebo-controlled phase 2 study. Specific aim is to evaluate feasibility and safety of anti-IL-1 (interleukin 1) treatment in the course of standard therapy for diabetic ketoacidosis in children and its effect on intracranial pressure.

NCT ID: NCT01341379 Withdrawn - Clinical trials for Inborn Errors of Metabolism

Increasing Ureagenesis in Inborn Errors of Metabolism With N-Carbamylglutamate

Start date: December 2010
Phase: Phase 2
Study type: Interventional

Hyperammonemia, which can cause brain damage, occurs in many different kinds of inborn errors of metabolism. The investigators propose to determine if short-term (3 day) treatment with N-carbamylglutamate can diminish hyperammonemia by enhancing ureagenesis in these patients. The investigators propose here a short-term (3 day) trial. If it succeeds, the investigators would consider more extensive long-term studies of the drug.