Clinical Trials Logo

Acidosis, Lactic clinical trials

View clinical trials related to Acidosis, Lactic.

Filter by:
  • Recruiting  
  • Page 1

NCT ID: NCT04766008 Recruiting - Clinical trials for Coronary Artery Disease

Metformin in Diabetic Patients Undergoing Coronary Angiography

NO-STOP
Start date: January 15, 2020
Phase: Phase 4
Study type: Interventional

The present study aims to evaluate the strict application of the 2018 European Society of Cardiology guidelines on myocardial revascularization, that recommends to check renal function if patients have taken metformin immediately before angiography and withhold metformin if renal function deteriorates. The aim of this study is to assess the safety of metformin in diabetic patients undergoing coronary angiography in terms of risk of lactic acidosis and to individuate eventual predictors of augmented lactate after coronary angiography.

NCT ID: NCT04762966 Recruiting - Clinical trials for Metformin Associated Lactic Acidosis

Study of Metformin Overdose

METINFO
Start date: March 1, 2021
Phase:
Study type: Observational

The objective of the METINFO study is an observational single-center retrospective and descriptive study. The main objective is to estimate the real mortality rate associated to a Metformin overdose. Second objectives are to estimate the real hospitalization rate related to metformin overdose and to identify the risk factors of a metformin overdose and especially the potential correlation between metformin blood concentration and overdose severity.

NCT ID: NCT03126890 Recruiting - Clinical trials for Peripheral Neuropathy

Investigation of the Correlation Between Plasma Concentration of Linezolid Antibiotic and Treatment Response and Adverse Reactions

Start date: November 1, 2016
Phase:
Study type: Observational

Linezolid is the second line agent in the treatment of MRSA and PRSP infections, and it is also the drug of choice for VRE infections. It can be an alternative option against multidrug resistant tuberculosis and non-tuberculosis mycobacterium. However, Patients who receive more than 2 weeks of treatment duration and who have renal dysfunction or severe cirrhosis may prone to experience anemia, thrombocytopenia, and leukopenia. Long-term use may also result in lactic acidosis, peripheral neuropathy and optic neuropathy due to mitochondrial toxicity. Thus, this study will analysis the medical charts in National Taiwan University Hospital (NTUH) from 2011 to 2016 to get the population demographics who use linezolid and analysis the occurrence rate of myelosuppression, neuropathy and lactic acidosis. Simultaneously, the investigators also use therapeutic drug monitoring (TDM) to prospectively evaluate the association of linezolid blood concentration and clinical efficacy and safety. The result of this study will provide physicians more information to prevent concentration-dependent adverse effects.