Achilles Tendon Pain Clinical Trial
Official title:
Impact of Peripheral Pain Perception on Central Sensitization and Movement Strategies in Patients With Chronic Achilles Tendinopathy
The purpose of this study is to better understand how the peripheral and central nervous system interact to produce the sensation of pain and motor patterns in patients with achilles tendinopathy (AT). These findings will motivate the development of future clinical studies that incorporate knowledge about pain processing and movement strategies in patients with tendinopathy. Participants with achilles tendinopathy will receive an anesthetic injection to the achilles tendon in order to examine how reduced pain, detected by the peripheral nervous system, alters task performance and perception of pain. We hypothesize that there are factors within the central nervous system that contribute to continued pain and disability in patients with chronic AT.
Twenty three people with Achilles tendinopathy (AT) and 23 people without AT will participate
in this single visit clinical study. Participants will rate their pain with pressure to the
heel, leg and elbow, climb stairs and perform a novel task in a motion capture system, and
complete questionnaires on how pain affects their daily life. All subjects will complete
these measures twice, and for participants with AT they will complete this battery of tests
before and after an anesthetic injection to the area of pain. This study has 2 aims:
Specific Aim 1 compares measures of altered central processing in patients with chronic AT to
adults without chronic pain; we hypothesize that patients with chronic AT will demonstrate
signs of altered central processing, including central sensitization (lower pressure pain
threshold), psychosocial factors (higher kinesiophobia), and/or altered motor control (lower
ankle power during stair ascent).
Specific Aim 2 determines which indicators of altered central processing persist after a
local anesthetic injection to the Achilles tendon in patients with chronic AT; we hypothesize
chronic AT pain is perpetuated by altered central processing that persists in the absence of
continued peripheral nociception.
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