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Clinical Trial Summary

This study is a non-intervention, multicenter study to address biomarkers of acetaminophen toxicity in children. Specifically, the study will examine acetaminophen (APAP) protein adducts and markers of liver injury in the blood samples of hospitalized children and adolescents who are receiving standard doses of acetaminophen, and children and adolescents who are status post acetaminophen overdose. Ultimately, the data generated from this study will be used to establish second generation biomarkers of acetaminophen toxicity, based on specific adduct proteins, which can be used in future risk assessment studies of children receiving acetaminophen.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT01005173
Study type Observational
Source Arkansas Children's Hospital Research Institute
Contact
Status Enrolling by invitation
Phase N/A
Start date August 2009

See also
  Status Clinical Trial Phase
Active, not recruiting NCT02322879 - Protective Effects of Propylene Glycol in Daily Acetaminophen Dosing Phase 4
Completed NCT03451487 - A Randomized, Single-blind, Parallel Group and Multiple - Dose Design Study N/A
Completed NCT01465542 - Treatment of APAP Toxicity With IV and Oral NAC 2008-2011
Completed NCT01575847 - Adduct Dipstick for Diagnosis of Acetaminophen Toxicity N/A
Completed NCT00725179 - Treatment of Acetaminophen Toxicity With N-acetylcysteine N/A