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Abortion, Missed clinical trials

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NCT ID: NCT05516810 Recruiting - Clinical trials for Abortion, Spontaneous

The Accuracy of Ultrasound Diagnosis of Hydatidiform Moles

Start date: October 19, 2021
Phase:
Study type: Observational

This is a prospective observational study assessing which ultrasound findings are best at excluding a molar pregnancy in first trimester miscarriage.

NCT ID: NCT05342467 Recruiting - Missed Abortion Clinical Trials

Gemeprost Versus Dinoprostone in First Trimester Miscarriages

Start date: November 11, 2021
Phase: Phase 2
Study type: Interventional

Comparison between gemeprost and dinoprostone to evacuate first trimester miscarriages.

NCT ID: NCT05124314 Recruiting - Abortion, Missed Clinical Trials

Comparison of Two Different Drug Regimens for Medical Treatment of Early Pregnancy Loss

Start date: October 27, 2021
Phase: Phase 4
Study type: Interventional

The purpose of this study is to compare the safety and efficacy of a combination of two drugs (mifepristone and misoprostol) to only one of these drugs (misoprostol) in medical management of missed miscarriage up to 13+6 weeks of pregnancy (early pregnancy loss). The investigators aim to enroll 220 patients within two years which would be enough to determine the difference between these two treatments with confidence.

NCT ID: NCT04705324 Recruiting - Clinical trials for Intrauterine Adhesion

Dilation and Curettage Versus Operative Hysteroscopy for Missed Abortion

Start date: January 21, 2022
Phase: N/A
Study type: Interventional

Randomizedtrial comparing success and complication rates of operative hysteroscopy versus traditional dilation and curettage (D&C) in the management of first trimester missed abortion.

NCT ID: NCT03813849 Recruiting - Miscarriage Clinical Trials

Remnants of Conception After Suction Evacuation of Missed Abortion

Start date: June 10, 2016
Phase:
Study type: Observational

All women admitted for surgical evacuation of missed abortion after failure of medical treatment from June 2016 underwent transvaginal sonography immediately after completion of the procedure as judged by the operator to ensure absence of remnants.

NCT ID: NCT03698734 Recruiting - Missed Abortion Clinical Trials

Evening Primrose Oil Efficacy in Second Trimester Abortion

Start date: November 1, 2018
Phase: Phase 3
Study type: Interventional

efficacy of evening primrose oil in shortening the duration of induction in 2nd trimesteric missed abortion

NCT ID: NCT03628625 Recruiting - Miscarriage Clinical Trials

Letrozole Pretreatment With Misoprostol fInduction of Abortion In First-Trimester Missed Miscarriage

Start date: September 10, 2018
Phase: Phase 2
Study type: Interventional

This study compares the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of first trimester pregnancy.

NCT ID: NCT03081104 Recruiting - Missed Abortion Clinical Trials

Operative Hysteroscopy and Ultrasound Guided Vacuum Aspiration Versus Blind Vacuum Aspiration for the Treatment of Missed Abortion

Start date: March 31, 2017
Phase: N/A
Study type: Interventional

The intervention to be evaluated are operative hysteroscopy(group A) and ultrasound guided aspiration(group C) and blinded vacuum aspiration(group B). For all surgical procedures , surgical antibiotics prophylaxis, misoprostol to dilate cervix, and anti adhesion barrier gel will be used. The evacuated retention products will be sent for pathological examination. Group A: Operative Hystroscopy: The procedure will be performed under general anaesthesia with the patient in lithotomy position. the cervix is grasped with pozzi forceps and dilated up to hegar 9 to facilitate insertion of the hysteroscopy. The uterine cavity will be distended with saline or glycine, with a maximum irrigation pressure of 110mmHg. The retained products will be resected from top to bottom with surgical resector without electric power. The use of forceps or curettes to facilitate the removal of material is permitted. . Group B:blinded vacuum aspiration of gestational contents: The women were allowed to empty their urinary bladder before induction of anesthesia, After positioning the patient appropriately on the operating table, bimanual pelvic examination was performed under anesthesia to assess the axis and the size of the uterus. A Sim's speculum was inserted into the vagina; the cervix was visualized and grasped using the Vulsellum forceps. The cervical canal was dilated gradually with Hegar dilators up to the size corresponding to the weeks of gestation. The uterine cavity was evacuated using a plastic cannula attached to an electric suction apparatus. Negative pressure of 75 mmHg was used. The aspirate was examined to confirm the presence of products of conception. The completeness of the evacuation was checked by gentle sharp curettage and final suctioning at the end of procedure. Group C: Ultrasound guided aspiration curettage : same as group B but guided with ultrasound

NCT ID: NCT02917785 Recruiting - Abortion, Missed Clinical Trials

Testing the Efficiency of Karman Curette in the Treatment of Misoprostol Failure in Women With Missed Abortion

Start date: October 2016
Phase: N/A
Study type: Interventional

the purpose of this study is to examine the success rates of Karman curettage in completing the abortion after failed recurred treatment with Misoprostol for women with missed abortion.

NCT ID: NCT02573051 Recruiting - Missed Abortion Clinical Trials

Termination Of Anembryonic Pregnancy

Start date: June 2015
Phase: Phase 2
Study type: Interventional

Anembryonic pregnancy is a leading cause of early miscarriage. The American Pregnancy Association estimates that blighted ovum causes approximately 50 percent of all first-trimester miscarriages. About 20 percent of all pregnancies result in miscarriage. In general, there are 3 options for management of anembryonic pregnancy: expectant, medical, and surgical management. Expectant management consists of no intervention and awaiting natural passage of tissue. Medical management uses medication to expel uterine tissue. Surgical management is defined by mechanical removal of tissue from the uterus. Medical management allows patients to avoid surgery and anesthesia. Patients may also feel that medical management is more private, and under their control. Several medications have been studied for medical management. Misoprostol, a prostaglandin E1 analogue, is a uterotonic that results in cervical softening and contractions that expel the products of conception. It may be administered vaginally, orally, buccally, or sublingually. Adverse effects vary based on route of administration. There is published literature on a wide range of therapeutic misoprostol regimens. Optimal dose and route of administration of misoprostol have not been determined by randomized trials. Overall, misoprostol is safe and well-tolerated. Patients receiving misoprostol vaginally rather than orally have decreased adverse gastrointestinal effects and prolonged duration of action. Oral misoprostol is less effective than vaginal misoprostol in emptying the uterus. Sublingual misoprostol is equivalent to vaginal misoprostol in inducing complete uterine emptying but is associated with more frequent diarrhea. When compared with lower dosages, a dose of 800 µg vaginal misoprostol is more effective at completing uterine emptying, although it results in a similar incidence of nausea. Based on international trials in settings with limited resources, WHO recommends a single vaginal dose of 800 µg misoprostol for medical management of anembryonic pregnancy. Routes of misoprostol administration include oral, vaginal, buccal or rectal. Vaginal misoprostol is associated with a greater overall exposure to the drug and greater effects on the cervix and uterus. Isosorbide mononitrate (IMN) is a drug used principally in the treatment of angina pectoris, which acts by dilating the blood vessels so as to reduce blood pressure.