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Abnormal Mental State clinical trials

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NCT ID: NCT01250847 Recruiting - Schizophrenia Clinical Trials

Effects of 'Seroquel-XR' on the Improvement of Neurocognitive Function in People At-risk Mental States(ARMS)

Start date: November 2010
Phase: Phase 4
Study type: Interventional

The primary objective of this study is to assess the effects of 'Seroquel-XR' on the verbal learning ability in people with at-risk mental state (ARMS) over a 12 week period. The verbal learning ability will be indexed by delayed free recall score of CVLT(California Verbal learning Test), a standard neuropsychological verbal memory tests. The secondary objective is to assess the effects of 'Seroquel-XR' on other cognitive function and psychiatric symptoms including psychotic, anhedonic symptoms, and impulsivity. The cognitive function abilities will be measured by standard neuropsychological tests as follows; - Working memory: verbal & spatial 2-back test - Attention: Digit Span, 3-7 CPT(Continuous Performance Test) - Executive function: WCST (Wisconsin Card Sorting Test) - Visuo-spatial ability: Rey Complex Figure Task copy - Visuomotor speed and planning: Trail making test A & B - Verbal fluency: Controlled Oral Word Association Test(COWAT) The scales of psychiatric symptoms which will be used are as follows; - Psychotic symptoms: Scales of Prodromal scales (SOPS), Positive and negative syndrome scale (PANSS) - Anhedonia: Social Anhedonia Scale (SAS), Physical Anhedonia Scale (PAS) - Social cognition: Ambiguous Intention Hostility Questionnaire (AIHQ) - Impulsivity: Barrett Impulsivity Scale (BIS)