Abdominal Obesity Clinical Trial
Official title:
The Belly Fat Study: Nutritional Intervention to Improve Metabolic Health in Subjects With Increased Abdominal Adiposity
In the Belly Fat study, the effects of two different caloric-restricted diets on metabolic
health will be examined in male and female subjects with increased abdominal adiposity (BMI
>27 kg/m2). Metabolic health is defined as health of the primary metabolic organs the liver,
gut and the adipose tissue, examined in a static state as well as after the application of a
challenge test.
The diets are equally caloric-restricted, but differ in nutrient composition. It is
hypothesized that one of the two diets causes a larger improvement in organ health and
reduction in liver fat.
Rationale: It is known that in particular visceral fat (abdominal obesity) and fat
deposition in non-adipose tissue such as the liver are important factors related to
metabolic health, such as the degree of insulin resistance, dyslipidaemia and other
well-established cardio-metabolic risk factors. The arise of pathological consequences of
abdominal obesity are a result of a disturbance in the elegant interplay between metabolic
organs, such as the liver, adipose tissue and gut. Several nutrients have demonstrated to
exert positive or negative effects on the health and functioning of metabolic organs. A diet
(whole dietary approach) can thus be a power tool to improve the health status of
individuals with abdominal obesity by improving organ health.
Objective: The primary objective of this study is to compare the effects of two different
diets on the static metabolic health status as assessed by determination of organ health
and, more specifically, of lipid accumulation in the liver. The application of a mixed meal
challenge test will be used to gain insight in the dynamic metabolic health status. A
secondary objective is to determine the reaction (brain activity) of individuals with
abdominal obesity after visual and olfactory food-cues.
Study design and intervention: Randomized, parallel design consisting of three groups:
1. 40 subjects, 12-wk nutritional intervention based on dietary advice: diet with 30%
caloric restriction and a Western style nutrient composition
2. 40 subjects, 12-wk nutritional intervention based on dietary advice: diet with 30%
caloric restriction with a nutrient composition aimed at improving organ health and
reducing liver fat
3. 30 subjects, control group, no nutritional intervention (optional: dietary advice at
the end of the study period)
Measurements on metabolic health will be conducted at baseline and after 12-wk intervention
and include:
- MR imaging for determining body fat distribution
- MR spectroscopy for quantification of liver fat
- Blood sampling (plasma and PBMCs) before and several timepoints after mixed meal
challenge
- Adipose tissue sampling before and after mixed meal challenge
- Vascular measurements before and after mixed meal challenge
- Urine and feces sampling
Study population: Males and females, 40-70 yrs old, BMI > 27 kg/m2
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label
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