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AA Amyloidosis clinical trials

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NCT ID: NCT06397001 Active, not recruiting - AA Amyloidosis Clinical Trials

Treatment of AA Amyloidosis

Start date: November 28, 2023
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the safety and efficacy of a subcutaneous injection of nL-SAA1-01in a patient with AA Amyloidosis.

NCT ID: NCT06354322 Not yet recruiting - Clinical trials for Autoinflammatory Disease

Unclassified GENotypes of Autoinflammatory Diseases and AA Amyloidosis

IPHYGENI MAI
Start date: May 2024
Phase:
Study type: Observational

Patients with autoinflammatory diseases (AID) have recurrent episodes of systemic inflammation accompanied by nonspecific elevation of blood inflammation markers typically absent between attacks. A complication of autoinflammatory diseases is AA amyloidosis, which can lead to renal failure and dialysis. Advances in genetic analysis have led to the identification of new autoinflammatory diseases and thus new pathophysiological pathways. However, genetic analyses are sometimes confronted with results that are difficult to interpret. These are the Variants of Unknown Significance, for which genetic analysis alone does not allow to determine if the genetic mutation is responsible for the symptoms. genetic analysis sometimes has limitations in the diagnosis of AID which can only be overcome by pathophysiological studies of the variants found.

NCT ID: NCT02704065 Completed - AA Amyloidosis Clinical Trials

Recurrent AA Amyloidosis After Renal Transplantation

Start date: February 2016
Phase: N/A
Study type: Observational

End-stage renal disease related to AA amyloidosis is well characterized but there is limited data concerning patient and graft outcomes after renal transplantation. The aim of this study is to evaluate the clinical features of, and risk factors for recurrent AA amyloidosis, as well as the effects of these factors on the ultimate outcome of renal allografts.