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21-Hydroxylase Deficiency clinical trials

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NCT ID: NCT01862380 Active, not recruiting - Clinical trials for Adrenal Hyperplasia, Congenital

Adrenocortical Functions in Women With Nonclassical 21-hydroxylase Deficiency.

EVAF-21
Start date: February 2013
Phase: N/A
Study type: Interventional

The risk of adrenal insufficiency in patients with nonclassical congenital adrenal hyperplasia due to 21-hydroxylase deficiency is not well documented. Indication of cortisol replacement therapy in situation of acute stress or at long term is thus controversial. The mineralocorticoid reserve of these patients has never been evaluated. Hypothesis: The glucocorticoid and mineralocorticoid function of the adrenal glands in women with nonclassical 21-hydroxylase deficiency is comparable with the adrenal functions of healthy age- sexe- and BMI-matched subjects.