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1p19q Codeletion clinical trials

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NCT ID: NCT04702581 Not yet recruiting - Oligodendroglioma Clinical Trials

A Randomized Trial of Delayed Radiotherapy in Patients Low-grade Oligodendrogliomas Requiring a Treatment Other Than Surgery

POLO
Start date: June 2021
Phase: Phase 3
Study type: Interventional

Because of their prolonged survival, patients with 1p/19q-codeleted low-grade oligodendrogliomas treated with RT + PCV are at risk of neurocognitive deterioration. We make the hypothesis that withholding radiotherapy until tumor progression could reduce the risk of neurocognitive deterioration without impairing overall survival.