Wrinkle Clinical Trial - Threads Insertion in Forehead Static Wrinkles

Status Completed

Clinical Trial Summary

The main objective of this study is to analyze the efficacy and safety of PDO threads in correcting deep static wrinkles on the upper face.

Clinical Trial Description

The upper face is a complex and dynamic part of the face, which conveys facial expression and emotion. As one age, youthful dynamic facial lines on the forehead and glabella change to static wrinkles, which remain on the face at rest. These permanent wrinkles can lead to the appearance of fatigue and negative facial expressions such as anger, which may influence psychological wellbeing, social confidence, and self-esteem. The two major factors involved in the formation of static wrinkles in the upper face are repetitive muscle contraction and aging (loss of dermal collagen and matrix material leading to reduced dermal support). Compared with other facial muscles, the frontalis and corrugator muscles usually retain their muscle volume and even undergo hypertrophy to compensate for age-related ptosis and loss in visual acuity, which intensify the wrinkles. Botulinum toxin and filler injections are currently the main treatment modalities in the management of facial wrinkles, especially for those on the upper third of the face. Conceptually, botulinum toxin addresses wrinkles by relaxing the muscles responsible for their creation (ie, the"dynamic" component), while soft tissue fillers provide necessary volume for the effacement of facial rhytids (ie, the "static" component). Although popular and widely accepted by the general population, some hesitate to receive toxin or filler injections due to the potential risk of unnatural facial expression, ptosis (associated with botulinum toxin), skin necrosis, and vision loss (from filler injection). This has created a demand for a minimally invasive technique with reduced side effects, where threads may be considered. Although more commonly known as a mean for facial lifting, polydioxanone (PDO) suture materials have been applied to static wrinkles with promising outcomes. ;

Study Design

Related Conditions & MeSH terms

Wrinkle

Clinical Trial Details

NCT number	NCT06179082
Study type	Interventional
Source	Zagazig University
Contact
Status	Completed
Phase	N/A
Start date	February 1, 2023
Completion date	November 15, 2023

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05098912` - Comparing Polydioxanone Thread Embedding Acupuncture and Manual Acupuncture for Nasolabial Fold Reduction	N/A
Completed	`NCT05271136` - A Clinical Study to Evaluate the Efficacy of an Anti-Aging Serum	N/A
Completed	`NCT05096247` - Post Market Study To Collect Efficacy Data For The Treatment Of Wrinkles With A Radiofrequency Device	N/A
Completed	`NCT05097157` - Study To Assess A Radiofrequency Microneedling Device For Dermatologic Conditions	N/A
Completed	`NCT04128046` - The Effect of Platelet-rich Fibrin Matrix on Skin Rejuvenation	N/A
Active, not recruiting	`NCT04727099` - Clinical Evaluation to Demonstrate the Safety and Performance of the Candela PicoWay System™	N/A
Active, not recruiting	`NCT06140628` - A 28-day Clinical Study on Facial Skin Rejuvenation	N/A
Not yet recruiting	`NCT05524779` - BTL-785F Device for Non-invasive Reduction of Wrinkles and Overall Facial Improvement	N/A
Completed	`NCT05514782` - A Clinical Study to Evaluate the Long-Term Efficacy and Tolerability of a Daily Anti-Aging Daily Serum	N/A
Completed	`NCT06123572` - A Clinical Study to Assess the Safety and Effectiveness of Anti-Ageing and Skin Brightening Gel	N/A
Completed	`NCT04911374` - An Open-Label Clinical Study to Evaluate the Efficacy of a Face Cream and Eye Cream	N/A
Recruiting	`NCT04989361` - Soluble Hyaluronic Acid Microneedle VS. Non-ablative Fractional Laser on Infraorbital Wrinkles.	N/A
Recruiting	`NCT04540900` - A Phase I Study of KB301, a Replication-Incompetent, Non-Integrating Vector Expressing Human Type III Collagen (COL3) for the Treatment of Superficial Skin Depressions	Phase 1
Recruiting	`NCT06074276` - The Effects of Almond on Facial Skin Collagen and Wrinkles	N/A
Recruiting	`NCT06202274` - Clinical Study to Evaluate the Safety and Efficacy of Candela Technology	N/A
Completed	`NCT06366503` - Evaluating Procedure Pairing of a Post-Procedure Cream Versus a Comparator in Patients Treated With Fractional Ablative CO2 Laser for Facial Rejuvenation	N/A
Active, not recruiting	`NCT06219278` - A Retrospective Review Evaluating the Matrix Pro Applicator for Treatment of Wrinkles	N/A
Active, not recruiting	`NCT06192550` - Functional Usability and Feasibility Testing of the Profound Matrix™ System	N/A
Completed	`NCT04650620` - Study to Evaluate the Performance and Safety of the Medical Device Plenhyage®	N/A
Completed	`NCT03729700` - The Effect of Almonds on Facial Aesthetics and Modulation of the Microbiome and Lipidome	N/A