Clinical Comparison of Topical Application of Alvogyl Versus Hyaluronic-Acid Gel in Management of Pain And Palatal Wound Healing

Wound Healing Clinical Trial

Official title:

Clinical Comparison of Topical Application of Alvogyl Versus Topical Application of Hyaluronic-Acid Gel in Management of Pain And Palatal Wound Healing : A Randomized Controlled Clinical Trial

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05334745
• Other study ID #: 01005007001
• Status: Recruiting
• Phase: Phase 1
• Start date: December 1, 2021
• Est. completion date: January 1, 2023

Study information

• Verified date: April 2022
• Source: Cairo University
• Contact: mohy eldin aboelazayem, TA
• Phone: +201005007001
• Email: mohy.aboelazayem[@]dentistry.cu.edu.eg
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of the study is to evaluate the effect of application of Alvogyl versus hyaluronic acid in decreasing postoperative pain and promoting healing in the palatal wound following the free gingival graft procedure

Description:

Postoperative pain and bleeding are the most common complications after palatal graft harvesting, also postsurgical swelling have been reported. Although hemostatic agents, mechanical barriers, bioactive materials, antibacterial and antiseptic agents and herbal products have been found effective in preventing such complications, an ideal support could not be specified for this purpose. Further, undesired side effects such as delayed wound healing/foreign body reaction have been reported . No gold standard has been identified, thus there is a need for further investigations aiming to reach the best possible treatment modality for pain relief and prevention of reported complications following harvesting of palatal graft .

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 16
• Est. completion date: January 1, 2023
• Est. primary completion date: December 1, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• Patients with mucogingival defects scheduled for free gingival graft
• Age from 18 years up to 60
• Medically healthy patient

Exclusion Criteria:

• Systemic diseases that may be a contraindication for any surgeries.
• Loss of maxillary premolars and molars.
• Pregnancy or lactation
• Smoking

Related Conditions & MeSH terms

• Wound Healing
• Wounds and Injuries

Intervention

Other:
• Alvogyl
application of Alvogyl in the palatal wound with stent versus hyaluronic acid application

Locations

Country	Name	City	State
Egypt	Egypt	Cairo

Sponsors (1)

Lead Sponsor	Collaborator
Cairo University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	postoperative pain	Pain through one week using the visual analogue scale (VAS)	7th days
Secondary	Wound healing	Wound healing index through one month .; The healing index has 5 grades which are 5(excellent healing), 4(very good healing), 3 (good healing), 2(poor healing) and 1(very poor healing)	7th, 14th, 21st and 30th days.