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NCT05868603 Clinical Trial

Effect of Different Remineralization Gels

White Spot Lesion Clinical Trial

Official title:
Effect of Different Remineralization Gels on the White Spot Lesions

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT05868603
Other study ID # müdf.24.04.23
Secondary ID
Status Not yet recruiting
Phase N/A
First received
Last updated
Start date May 24, 2023
Est. completion date April 1, 2025

Study information
Verified date May 2023
Source Marmara University
Contact Betul Sen Yavuz, DDS
Phone +905399887646
Email dt.betulsen@gmail.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The aim of the study is to treat white spot lesions that occur after orthodontic treatment. Different gels will be used for remineralization. The study will consist of 45 people between the ages of 15-18. 45 people will be divided into 3 groups.

Description:

Oral hygiene training will be given to each group and a toothpaste containing 1450 ppm fluoride will be given to brush their teeth twice a day. Essix appliance with reservoir will be made by taking impressions from 30 patients. Remineralization gel will be put into the Essix appliance for 5-7 minutes twice a day for one month.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 45
Est. completion date April 1, 2025
Est. primary completion date October 1, 2024
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 15 Years to 18 Years
Eligibility Inclusion Criteria: - Patients aged 15-18 years, - Presence of white point lesions, - Volunteering to participate in the research. Exclusion Criteria: - Not having received orthodontic treatment, - Having a developmental anomaly affecting the enamel, - Being allergic to milk, - Having a syndrome affecting the oral cavity.

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Remineralization gel
Remineralization gel

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Marmara University

Outcome
Type Measure Description Time frame Safety issue
Primary Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) Decrease in laser fluorescence values with Diagnodent Pen as an indicator of remineralization 4 weeks
Secondary Calcium glycerophosphate Decrease in laser fluorescence values with Diagnodent Pen as an indicator of remineralization 4 weeks
See also
  Status Clinical Trial Phase
Completed NCT05710874 - A Prospective, Randomized, Clinical Study on the Effects of CPP-ACP-paste, Fluoride and a Combination on the Evolution of White Spot Lesions in Orthodontic Patients After Debonding. N/A
Completed NCT04107012 - Evaluation of Enamel Demineralization During Clear Aligner Orthodontic Treatment N/A
Active, not recruiting NCT04342858 - Prospective Randomized Controlled Trial for Prevention of Demineralization During Fixed Orthodontic Treatment Phase 2
Recruiting NCT05989750 - Air-polishing With Erythritol During Orthodontic Tretament N/A
Completed NCT06200129 - İmportance of Scattered White Spots Detected in the Duodenum and Their Relationship wıth Zonulin N/A
Not yet recruiting NCT03976583 - Remineralization Potential of Pearl Powder Compared to CPP-ACP on Enamel White Spot Lesions Phase 2
Not yet recruiting NCT06051981 - White Spot Lesions Treatment in Orthodontic Phase 4
Not yet recruiting NCT04422860 - Remineralization Efficacy of Gum Arabic Varnish. Phase 2/Phase 3
Completed NCT04560478 - Comparing Fluoride Varnish and Sealant to Prevent White Spots in Orthodontic Patients N/A
Completed NCT02027922 - Clinical Effectiveness of Various Professionally Applied Fluoride Prophylaxes in Groups at High Risk N/A
Completed NCT04908293 - Home Remineralization of White Spot Lesions With Two Different Toothpastes. N/A
Not yet recruiting NCT06331442 - The Effect of Photodynamic Therapy on Plaque in Orthodontic Patients N/A
Not yet recruiting NCT05306691 - Remineralizing Efficacy of Giomer Varnish vs. Fluoride Varnish in Management of White Spot Lesions in Adult Patients Early Phase 1
Active, not recruiting NCT06166849 - Clinical Evaluation of an Experimental Remineralization Product N/A
Completed NCT05775250 - Evaluation of Two Varnishes on the Improvement of White Spot Lesions in Children N/A
Completed NCT03114475 - Effect of CO2 Laser on Enamel White Spot Lesion Formation Around Orthodontic Brackets N/A
Active, not recruiting NCT06403371 - The Effect of Fluoride Varnish on White Spot Lesion in Clear Aligner Orthodontic Patients N/A
Completed NCT05771077 - Effect of Poly Amido Amine Dendrimer, Nano-hydroxyapatite Phase 1
Completed NCT05721586 - Self-assembling Peptide With Sodium Fluoride in Treating White Spot Lesionss in Primary Teeth N/A
Completed NCT04671134 - Evaluation of State and Shade of White Spot Lesions After Using Different Remineralizing Agents (An in Vivo Study) N/A