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White Spot Lesion clinical trials

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NCT ID: NCT05306691 Not yet recruiting - White Spot Lesion Clinical Trials

Remineralizing Efficacy of Giomer Varnish vs. Fluoride Varnish in Management of White Spot Lesions in Adult Patients

Start date: May 15, 2022
Phase: Early Phase 1
Study type: Interventional

To evaluate the remineralizing capability of biosmart S-PRG barrier coat varnish and its employment in clinical practice

NCT ID: NCT05139966 Completed - White Spot Lesion Clinical Trials

Fluoride Controlled-release System for Initial Lesions of Caries

Start date: August 3, 2017
Phase: Phase 2/Phase 3
Study type: Interventional

OBJECTIVE: To evaluate in vivo the efficacy of fluoride-containing dentifrice incorporated in a controlled-release system (F-CSL, patent pending) in the remineralization of white spot lesions of caries in caries-active individuals. METHODS: A double-blind randomized clinical trial to evaluate the bioavailability of intraoral fluoride in biomarkers of exposure (biofilm and saliva) after the use of experimental toothpaste in the control of dental caries. The study will last three months. The participants of the study will be divided into three groups according to the dentifrice used. The sample will be selected randomly and composed of children and adolescents who seek the service of cariology of the UFPB. There will be participants of both sexes, preferably of the metropolitan region of João Pessoa in order to guarantee the low fluorine exposure by the water of supply. Intrabucal photographs will be obtained. Samples of saliva will be collected after 3 hours of the last meal. The benefits will be achieved by obtaining the reduction of the white spot area (mm2) plus the fact that all the children will be examined and will receive information on the treatment needs and forwading for the same.

NCT ID: NCT05001035 Completed - White Spot Lesion Clinical Trials

Effect of Different Biomimetic Materials on White Spot Lesions in Enamel

Start date: July 1, 2021
Phase: N/A
Study type: Interventional

This study will be conducted to evaluate: 1- The remineralizing effect of different biomimetic materials (Zinc carbonate hydroxyapatite nanoparticles, Poly-amido amine (PAMAM) and bioactive glass nanoparticles) on white spot lesions in enamel. 2- The clinical efficacy of these agents on disappearance of these white spots.

NCT ID: NCT04929509 Recruiting - White Spot Lesion Clinical Trials

P11-4 and Nanosilver Fluoride Varnish in Treatment of White Spot Carious Lesions

Start date: December 5, 2020
Phase: N/A
Study type: Interventional

Background: Great efforts have been undertaken for dental caries prevention. Among the recent remineralizing materials, Nano silver fluoride varnish products which are based on nanotechnology have been proposed for "repairing" enamel . Regenerative medicine-based approaches for caries treatment focus on biomimetic remineralization of initial carious lesions as a minimal invasive therapy using Self-Assembling Peptide P11-4 (Curodont Repair) which enhances remineralization of white spot lesions. Purpose of the Study: The aim of this study is to compare clinically and microbiologically the therapeutic effect of Self Assembling Peptide P11-4 (Curodont Repair), nano silver fluoride varnish and 5% fluoride varnish (Duraflor) on remineralization of enamel White Spot Lesions in permanent teeth of adults.

NCT ID: NCT04908293 Completed - White Spot Lesion Clinical Trials

Home Remineralization of White Spot Lesions With Two Different Toothpastes.

Start date: May 28, 2021
Phase: N/A
Study type: Interventional

The aim of the study is to compare white spot lesions before, during and after treatment with New Biorepair Advanced Sensitive toothpaste containing micro crystals of hydroxyapatite and Colgate toothpaste with 1450 ppm of fluoride. The timeline will consider the study begin, 15 days, 30 days and 90 days after the beginning of the study. The following indices will be recorded: BEWE Index, Schiff Air Index, VAS scale. After that, patients will fill in a satisfaction questionnaire.

NCT ID: NCT04705428 Completed - White Spot Lesion Clinical Trials

Preventive Therapy of White Spot Lesions Using Different Remineralizing Agents in Children From 3 to 12 Years Old

Start date: January 1, 2021
Phase: N/A
Study type: Interventional

Compare by clinical observation, photographs and fluorescence the efficacy of sodium fluoride, silanofluoride and thiefenfluoride in treating white spots.

NCT ID: NCT04673097 Not yet recruiting - White Spot Lesion Clinical Trials

Performance of Different Resin Infiltration Materials on White Spot Lesions: Clinical and Laboratory Assessments

Start date: December 19, 2020
Phase: N/A
Study type: Interventional

The study is a clinical controlled trial. Ethical approval will be obtained from Imam Abdulrahman bin Faisal University, Dammam. The study participants will be recruited from the dental hospital and conducted between November 2020 to November 2020. This will be a single-center, randomized, single blinded with a 1:1:1 allocation ratio for the application of Icon® resin infiltration, MI Paste Plus and both treatments

NCT ID: NCT04671134 Completed - White Spot Lesion Clinical Trials

Evaluation of State and Shade of White Spot Lesions After Using Different Remineralizing Agents (An in Vivo Study)

Start date: June 1, 2017
Phase: N/A
Study type: Interventional

The aim of the study is to evaluate the effect of Biomimetic remineralizing agent and resin modified glass ionomer varnish on color shade and state of white spot lesions immediately, after 3 months, and after 6 months. (An in vivo study).

NCT ID: NCT04560478 Completed - White Spot Lesion Clinical Trials

Comparing Fluoride Varnish and Sealant to Prevent White Spots in Orthodontic Patients

Start date: October 1, 2018
Phase: N/A
Study type: Interventional

The purpose of the study is o compare the efficacy of CPP-ACP MI Varnish and ProSeal sealant in preventing white spot lesion (WSL) formation in orthodontic patients.

NCT ID: NCT04422860 Not yet recruiting - Caries,Dental Clinical Trials

Remineralization Efficacy of Gum Arabic Varnish.

Start date: October 2020
Phase: Phase 2/Phase 3
Study type: Interventional

The aim of this study is to evaluate the remineralizing capacity of Gum Arabic varnish and its implementation into clinical practice.