Combined Application of Diode Laser & Different Remineralizing Agents on

Status Completed

Clinical Trial Summary

Dental caries is a very common condition, and although it has become less common, it still represents a serious public health risk. Caries symptoms range from the earliest molecular alterations in the tooth's apatite crystals to an apparent white spot lesion (WSL) or eventual cavitation. The white spot lesion looks chalky because minerals are being lost from both the surface and the underside of the enamel. A relatively simple and noninvasive caries preventive regimen in treating white spot lesions with low-level laser irradiation, either alone or with topical ﬂuoride treatment. This treatment results in reduced enamel solubility and dissolution.

Clinical Trial Description

The study was reviewed and approved by the "Ethical research committee "of the Faculty of Dental Medicine for Girls; at Al-Azhar University, Cairo, Egypt. This study was conducted on 90 teeth with white spot lesions (WSLs) detected clinically on the buccal surface of teeth. The patients with WSLs were selected randomly from the operative dentistry clinic at the Faculty of Dentistry, Girl's Branch, Al-Azhar University After examination, the teeth will be assigned into six groups of 15 teeth with white spot lesions each according to the remineralizing material used: - The first group (A1B1): The teeth with WSL will be treated with nano-hydroxyapatite +fluoride with laser application. - The second group (A1B2): The contralateral teeth will be treated with nano-hydroxyapatite +fluoride without laser application. - The third group (A2B1): The teeth with WSL will be treated with nano-hydroxyapatite + xylitol with laser application. - The fourth group (A2B2): The contralateral teeth will be treated with nano hydroxyapatite+ xylitol without laser application. - The fifth group (A3B1): The teeth with WSL will be treated with 5% sodium fluoride varnish with laser application. - The sixth group (A3B2): The contralateral teeth will be treated with 5% sodium fluoride without laser application. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05871619
Study type	Interventional
Source	Al-Azhar University
Contact
Status	Completed
Phase	N/A
Start date	May 5, 2022
Completion date	April 20, 2023

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See also
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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Combined Application of Diode Laser and Different Remineralizing Agents on White Spot Lesions — Whitespot

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms