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NCT01906411 Clinical Trial

Dopaminergic Function and Food Reward

Weight Loss Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01906411
Other study ID # DAD
Secondary ID
Status Completed
Phase N/A
First received July 8, 2013
Last updated May 28, 2015

Study information
Verified date May 2015
Source University Hospital Tuebingen
Contact n/a
Is FDA regulated No
Health authority Germany: Ethics Commission
Study type Observational

Clinical Trial Summary

The broad aim of the study is to obtain a better understanding of alterations in mesolimbic reward pathways in adiposity based on the hypothesis of a hypofunctioning reward system in obesity.

This will be achieved by integrating a functional neuroimaging (fMRI) with behavioral reward tasks and the modulation of the dopamine level by dopamine depletion.

Recruitment information / eligibility
Status Completed
Enrollment 36
Est. completion date
Est. primary completion date March 2014
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group 21 Years to 45 Years
Eligibility Inclusion Criteria:

- female

- healthy

Exclusion Criteria:

- fMRI contraindications

- claustrophobia

Study Design

Observational Model: Case-Crossover, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Intervention

Dietary Supplement:
• Dopamine depletion vs. Balanced aminoacid drink

Locations
Country Name City State
Germany University Clinic of Tuebingen, MEG Center Tuebingen

Sponsors (1)
Lead Sponsor Collaborator
University Hospital Tuebingen

Country where clinical trial is conducted

Germany, 

Outcome
Type Measure Description Time frame Safety issue
Primary Differential brain functions in the dopaminergic reward system differential brain fuctions will be measured by blood oxygen level dependent effect. 4 hours after intake of the dopamine depletion or balanced aminoacid drink No
Secondary amino acid level changes due to dopamine depletion 4 hours after intake of the dopamine depletion or balanced aminoacid drink No
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