The Effect of Quantitative EEG Combined With Ultrasound and Sputum Volume on Predicting Weaning Failure

Weaning Failure Clinical Trial

Official title:

The Effect of Quantitative Electroencephalography Combined With Ultrasound and Sputum Volume on Predicting Weaning Failure in Neurocritical Patients

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06359977
• Other study ID #: YB-202442
• Status: Not yet recruiting
• Start date: April 15, 2024
• Est. completion date: May 15, 2025

Study information

• Verified date: April 2024
• Source: Qingdao University
• Contact: bo yao, Dr.
• Phone: +8618661800691
• Email: icuyaobo[@]126.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Neurocritical patients often face the need for removal of endotracheal tubes. However, despite following the extubation criteria for general critical ill patients, neurocritical patients still exhibit a higher rate of weaning failure, significantly higher than that of general critical ill patients. The extubation criteria for general critical patients emphasize the assessment of lung conditions. However, neurological critical patients often have less severe lung damage, but factors such as consciousness level and coughing ability may significantly influence extubation. Quantitative EEG serves as an objective tool to reflect consciousness level status, while bedside ultrasound can assess respiratory muscle function. Additionally, sputum volume may reflect the condition of lung condition. Therefore, we believe that combination of these three indicators can better predict the success of extubation for neurocritical patients.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 50
• Est. completion date: May 15, 2025
• Est. primary completion date: April 15, 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Neurocritical patients with endotracheal intubation;
• Successful spontaneous Breathing Trial;
• The patients meet extubation criteria evaluated by clinical physician

Exclusion Criteria:

• Patients whose families have opted for cessation of treatment.

Related Conditions & MeSH terms

• Weaning Failure

Intervention

Other:
• Quantitative EEG monitoring and beside ultrasound evaluation
After successful spontaneous breathing trial, neurocritical patients undergo at least 2 hours of quantitative EEG monitoring before extubation. Additionally, bedside ultrasound assesses the thickness and variability of the diaphragm, intercostal muscles, rectus abdominis, transversus abdominis, and external oblique muscles. The sputum volume for the 24 hours prior to extubation is also recorded. Reintubation within 48 hours after extubation is defined as weaning failure.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Qingdao University

References & Publications (2)

Bosel J. Who Is Safe to Extubate in the Neuroscience Intensive Care Unit? Semin Respir Crit Care Med. 2017 Dec;38(6):830-839. doi: 10.1055/s-0037-1608773. Epub 2017 Dec 20. — View Citation

Welte TM, Gabriel M, Hopfengartner R, Rampp S, Gollwitzer S, Lang JD, Stritzelberger J, Reindl C, Madzar D, Sprugel MI, Huttner HB, Kuramatsu JB, Schwab S, Hamer HM. Quantitative EEG may predict weaning failure in ventilated patients on the neurological i — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Quantitative EEG indicators	These indicators including amplitude EEG and the proportion of a,ß,d,? wave	2 hours before extubation
Primary	Respiratory muscles thickness in centimeter	Muscle thickness was evaluated by ultrasound.	2 hours before extubation
Primary	Respiratory muscles thickening fraction (%)	Muscle thickening fraction was evaluated by ultrasound. It equals (end-inspiratory thickness - end-expiratory thickness)/end-expiratory thickness × 100%.	2 hours before extubation
Primary	Sputum volume in milliliter	The amount of sputum	24 hours before extubation