Vulvodynia Clinical Trial
The purpose of this study is to investigate the possibility of an association between Localized Provoked Vulvodynia (LPV) that is both severe and primary and polymorphic markers/single nucleotide polymorphisms (SNPs) in and around the genes encoding heparanase (HSPE-1), Vanilloid Receptor VR1 (TRPV1), and Nerve Growth Factor (NGF).
The short-term goal proposed for the current study was to investigate the possibility of an
association between Localized Provoked Vulvodynia (LPV) that is both severe and primary and
polymorphic markers/single nucleotide polymorphisms (SNPs) in and around the genes encoding
heparanase (HSPE-1), Vanilloid Receptor VR1 (TRPV1), and Nerve Growth Factor (NGF).
Eight polymorphic SNPs in the three different genes suspected to be involved in LPV has been
examined as follow:
1. HSPE gene: Four polymorphic SNPs: rs4693608, rs11099592, rs6856901 and rs4364254 that
were found to be informative in the Ashkenazi Jewish population
2. TRPV1 gene: Two polymorphic SNPs: rs222747 and rs8065080.
3. NGF gene: A novel T to C SNP in the promoter region at position -198 (rs11102930) and
rs6330 which was found to be associated with anxiety-related personality traits and has
been suggested to may affect intracellular processing and secretion of NGF.
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Observational Model: Case Control, Time Perspective: Cross-Sectional
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