5-fluorouracil for Treatment of Stable Vitiligo

Status Completed

Clinical Trial Summary

Vitiligo, a significant dermatologic challenge affecting 0.5 to 2% of the global population. Despite various existing medical approaches, current vitiligo treatments are still far from optimal.

Clinical Trial Description

Vtiligo, a significant dermatologic challenge affecting 0.5 to 2% of the global population. Despite various existing medical approaches, current vitiligo treatments are still far from optimal. 5FU is a well-known chemotherapeutic agent that has been used for colorectal cancer treatment. The drug prevents DNA synthesis by inhibiting the thymidylate synthetase. The hyperpigmenta-tion of the skin is the most side effect observed with 5-FU therapy which directed its use in treat-ment of vitiligo. Besides, many studies reported that 5-FU could induce regimentation in vitiligo by direct stimulation of melanocytes and increasing melanosomes numbers in the keratinocytes. ;

Study Design

Related Conditions & MeSH terms

Vitiligo

Clinical Trial Details

NCT number	NCT06209138
Study type	Interventional
Source	Al-Azhar University
Contact
Status	Completed
Phase	N/A
Start date	January 23, 2024
Completion date	April 15, 2024

View Details

See also
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