Vitiligo Clinical Trial
Official title:
Comparative Study of the Use of Trypsin Versus Dispase in Melanocyte-Keratinocyte Transplantation for the Treatment of Vitiligo
Previous studies have evaluated the transplantation of pigment cells (melanocytes)and skin
cells (keratinocytes) for the treatment of vitiligo. This procedure is known as MKTP
(Melanocyte Keratinocyte Transplantation Procedure). Multiple studies have found this
procedure to be both safe and effective for the treatment of vitiligo. The majority of these
studies utilized trypsin to help isolate melanocytes and keratinocytes. Trypsin is enzyme
that helps to separate the different layers of skin. However, some cell biologists believe
that the enzyme dispase (which can be used to separate the epidermis from the dermis) is
less toxic to cells of the epidermis and can result in a greater number of viable
melanocytes and keratinocytes for transplantation.
This study will look at the repigmentation rates of MKTP using trypsin to isolate cells,
versus MKTP using dispase to isolate cells.
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