Vitamin D Clinical Trial
Official title:
Longitudinal Study of Vitamin D Metabolism and Bone Healing in Adult Patients With Recent Long Bone Fracture
Studies in chickens show that blood levels of a particular form of vitamin D (called
24,25-dihydroxvitamin D) increase after bone fracture. Laboratory studies show that this
form of vitamin D helps the bone healing process in chickens. The investigators want to find
out whether blood levels of this form of vitamin D increase after bone fracture in humans.
Previous research studies have not addressed this question. The results of this research
could eventually lead to the development of new treatments to help bone healing after
fracture.
Patients will be asked to take part in this study if they are aged 16 years or older and
come to the Royal London Hospital with a broken bone in the arm or leg or collar bone
(clavicle). They will be asked to give a 20ml (about 4 teaspoons) blood sample on three
occasions: at the start of the study, at 5-14 days after the fracture; and at 4-10 weeks
after the fracture. The rest of their normal care would not be affected. Follow-up blood
samples will be timed to coincide with routine clinic visits which are scheduled as part of
normal clinical care. Patients' vitamin D level will be measured as part of the study, and
those who have a low vitamin D level will be informed about this, and advised about
appropriate vitamin D supplementation. The investigators will let the patient or their GP
know if any blood tests are abnormal
n/a
Observational Model: Cohort, Time Perspective: Prospective
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