Myocardial Function and Vitamin D Supplementation in Diabetes.

Vitamin D Deficiency Clinical Trial

— VitaDD  

Official title:

Effect of Vitamin D Supplementation on Myocardial Regional Function by Dobutamine Stress Echocardiography in Diabetic Patients.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03437421
• Other study ID #: UAPV-022018-SFC
• Status: Completed
• Phase: N/A
• Start date: February 4, 2018
• Est. completion date: November 19, 2023

Study information

• Verified date: November 2023
• Source: University of Avignon
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Vitamin D deficiency is recognized as a cardiovascular risk factor. Diabetic patients are of major risk for cardiovascular diseases and typically present with Vitamin D deficiencies. Myocardial function is altered in both type I and II diabetic patients but no data is today available on the effect of Vitamin D supplementation.

The aim of the study will be to investigate myocardial function (by deformation imaging techniques) at rest and during low-dose dobutamine stress echocardiography in both type I and II diabetic patients. Within each diabetic population, myocardial function will be compared at baseline between the vitamin D deficient and non-deficient individuals. Furthermore, the investigators will study the effect of a 3 month supplementation in those with deficiencies.

Description:

Rationale:

Vitamin D exerts a principal role in homeostasis of calcium and phosphorus. However, recent studies indicated also its important function in cell differentiation, proliferation and growth as well as regulation of the immune system.

Vitamin Deficiency is today recognized as a risk factor for cardiovascular disease (CVD). Diabetic patients are of major risk for CVD. They typically present with Vitamin D deficiencies. Experimental studies have established as a result of Vitamin D deficiency alterations in intrinsic cardiac contractile and relaxation properties, hypertrophy and fibrosis. Regional myocardial function is altered in both type I and II diabetic patients. In type II diabetic individuals, myocardial dysfunction is furthermore exacerbated in those with Vitamin D deficiency compared to those with normal levels. In patients free from CV risk and deficient in Vitamin D, regional myocardial function improved after Vitamin D supplementation. To the best of our knowledge, no scientific study is today available on the effect of Vitamin D supplementation on regional myocardial function in diabetic patients deficient in vitamin D.

Objectives and Methodology:

• To compare regional myocardial linear deformation and torsion, at rest and in response to a DB stress in diabetic patients deficient and non-deficient in Vitamin D.

• To evaluate the impact of vitamin D supplementation in those with vitamin D deficiency.

All the diabetic patients will benefit from a clinical (medical history, drug therapy, ECG, blood pressure, ...), anthropometric (abdominal obesity indices) and biological (carbohydrate and lipid balance, markers of inflammation and heart failure, vitamin D glucose and insulin status) evaluation. In addition, conventional echocardiography (remodelling and global diastolic and systolic function) complemented by a functional analysis by tissue Doppler imaging will be performed. Furthermore, 2D cine loops will be recorded in the apical 4, 3 and 2- chamber views for the assessment of regional myocardial longitudinal deformations as well as in the parasternal short axis (base, mid and apex) for the evaluation of circumferential deformations and basal and apical rotation and torsion, at rest and under low dose dobutamine (110 and 120 bpm).

Vitamin D supplementation:

Patients with vitamin D deficiency will be investigated before and after a 3 month cholecalciferol supplementation.

For this purpose 25-OH-D3 with be evaluated at baseline.

• Patients with 29≤ 25-OH-D3 ≥20 ng/mL will receive 200 000 UI orally the first month (100 000 UI at T0 + 100 000 UI at T0+15 days, UVEDOSE™ Laboratoires Crinex, Montrouge, France) followed thereafter for the last 2 months by one daily dose (5 drops orally = 1 000 UI/day, DÉDROGYL™ , DB Pharma, La Varenne-Saint-Hilaire, France).

• Patients with : 19≤ 25-OH-D3 ≥10 ng/mL will receive orally 300 000 UI (100 000 UI at T0 + 100 000 UI at T0+23days + 100 000 UI at T0+45days; UVEDOSE™ Laboratoires Crinex, Montrouge, France) followed thereafter for the last month by one daily dose (5 drops orally =1 000 UI/day, DÉDROGYL™ , DB Pharma, La Varenne-Saint-Hilaire, France).

• Patients with : 25-OH-D3 <10 ng/mL will receive orally 400 000 UI (100 000 UI at T0 + 100 000 UI at T0+15days + 100 000 UI at T0+30 days + 100 000 UI at T0+45days, UVEDOSE™ Laboratoires Crinex, Montrouge, France) followed thereafter for the last month by one daily dose (5 drops orally =1 000 UI/day, DÉDROGYL™ , DB Pharma, La Varenne-Saint-Hilaire, France).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 100
• Est. completion date: November 19, 2023
• Est. primary completion date: September 1, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 40 Years to 65 Years

Eligibility

Inclusion Criteria:

• Male and female 40-65 years old, asymptomatic and free from epicardial coronary artery disease.

Exclusion Criteria:

• body mass index > 35 kg / m2, defining severe obesity,

• Under insulin therapy (for Type II only)

• Poorly controlled hypertension (> 140/95)

• LV ejection fraction (LVEF) < 55%

• Peripheral vascular disease (> stage II of Leriche)

• Heart disease or known coronary artery disease,

• Known and poorly compensated thyroid dysfunction,

• Nocturnal apnea syndrome,

• Inability to give written informed consent,

• Chronic diseases,

• moderate to severe left ventricular hypertrophy :> 109 g / m2 in women and> 132 g / m2 in men and parietal thickness > 13mm.

• poor glycemic control (HbA1c > 9%)

• poor echogenicity

• severe autonomic or peripheral neuropathy,

• Severe diabetic retinopathy,

• Advanced Diabetic nephropathy (defined by documented proteinuria and/or renal failure).

Related Conditions & MeSH terms

• Diabetes Complications
• Myocardial Dysfunction
• Vitamin D Deficiency
• Vitamin D Supplementation

Intervention

Dietary Supplement:
• Vitamin D3 (cholecalciferol)
Patients with 29= 25-OH-D3 =20 ng/mL will receive 200 000 UI orally the first month (100 000 UI at T0 + 100 000 UI at T0+15 days, UVEDOSE™ Laboratoires Crinex, Montrouge, France) followed for the last 2 months by one daily dose (5 drops orally = 1 000 UI/day, DÉDROGYL™ , DB Pharma, La Varenne-Saint-Hilaire, France). Patients with : 19= 25-OH-D3 =10 ng/mL will receive orally 300 000 UI (100 000 UI at T0 + 100 000 UI at T0+23days + 100 000 UI at T0+45days; UVEDOSE™) followed for the last month by one daily dose (5 drops orally =1 000 UI/day, DÉDROGYL™ ). Patients with : 25-OH-D3 <10 ng/mL will receive orally 400 000 UI (100 000 UI at T0 + 100 000 UI at T0+15days + 100 000 UI at T0+30 days + 100 000 UI at T0+45days, UVEDOSE™) followed for the last month by one daily dose (5 drops orally =1 000 UI/day, DÉDROGYL™).

Locations

Country	Name	City	State
France	Hospital Henri Duffaut	Avignon	Paca

Sponsors (1)

Lead Sponsor	Collaborator
University of Avignon

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in longitudinal strain	Index of myocardial function measured using deformation imaging technique by echocardiography, at rest and under dobutamine stress.	Before and after 3 month of Vitamin D supplementation