Vitamin D Deficiency Clinical Trial
Official title:
The Efficacy of Vitamin D3 for the Treatment of Chronic Plaque Type Psoriatic Patients With Vitamin D Deficiency and Insufficiency: a Randomized Controlled Trial
The purpose of this research is to study whether vitamin D supplement can improve clinical outcome (PASI score) in psoriasis vulgaris with vitamin D insufficiency and deficiency.
While psoriasis is not a lethal disease, the disease itself can impact patients' quality of
life. Nowadays there are several researches on vitamin D functions. Recently review article
of vitamin D deficiency by Holick MF., stated that vitamin D can play a role in decreasing
the risk of osteoporosis and other chronic diseases such as malignancy, autoimmune disease,
infectious disease, cardiovascular disease, and psoriasis. Moreover, vitamin D effects on
keratinocyte by decreasing abnormal cell proliferation, differentiation, apoptosis and
controlling immunological process via the suppression of T-cell activation, regulation of
cytokine secretion patterns, induction of regulatory T-cell, modulation of T-cell
proliferation and interference with T-cell apoptosis.
Thus, our objective is to look for other alternative treatment, which may have less side
effects and acceptable clinical outcomes.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment
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|---|---|---|---|
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