Vitamin B 12 Deficiency Clinical Trial
Official title:
Diagnostics and Therapy of a Cobalamin Deficiency
In a retrospective study with existing values of vitamin B12 and holotranscobalamin 4
strategies are simulated and the results and costs are compared.
Generally, cobalamin ist substituted by intramuscular administration. However, oral
preparations are also available. Aims of the focus groups are to investigate the awareness of
a (potential) deficiency and to identify a therapy for best adherence.
Various diagnostic strategies exist for the identification of a cobalamin deficiency. In a
retrospective study with existing serum values of vitamin B12 and holotranscobalamin 4
strategies are simulated and the results and costs are compared.
A cobalamin deficiency can have various causes: Dietary habits (vegetarian, vegan), advanced
age, pernicious anaemia, gastrectomy, drug interactions (metformin, proton pump blocker).
Therapy is often performed by intramuscular administration of cobalamin. However, oral
preparations are also available in very different dosages. Investigators want to investigate
with focus groups whether different patient groups are aware of a (potential) deficiency, how
cobalamin is actually substituted (with registered or otherwise acquired products) and which
therapy would lead to best adherence.
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