Cyclosporine 0.05% Eye Drops for Vernal Keratoconjunctivitis Trial

Status Completed

Clinical Trial Summary

To observe and compare the clinical efficacy of cyclosporine 0.05% eye drops with Loteprednol Etabonate 0.5% and Tobramycin Eye Drops 0.3% in the treatment of Vernal Keratoconjunctivitis in developing regions of China.

Clinical Trial Description

Vernal keratoconjunctivitis (VKC) is an allergic disease that severely affects the eyesight of adolescents. Vernal keratoconjunctivitis (VKC) usually occurs in temperate regions such as the Mediterranean region, the Middle East, Africa, Central America, and the Indian subcontinent. In the EU an estimated 3.2 per 10,000 inhabitants (0.03%). It occurs repeatedly and mainly involves type I and type IV hypersensitivity. long-term standardized treatment is necessary. Therefore, this research aims to compare the readily available cyclosporine 0.05% eye drops and Loteprednol Etabonate 0.5% and Tobramycin Eye Drops 0.3% in developing regions of Asia (China, Jiangxi Province) for long-term drug use in VKC patients in developing countries provide evidence. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05353101
Study type	Interventional
Source	Second Affiliated Hospital of Nanchang University
Contact
Status	Completed
Phase	Phase 1
Start date	July 1, 2020
Completion date	June 1, 2021

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See also
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Completed	`NCT03464435` - A Novel Combined Therapy for Refractory Vernal Keratoconjunctivitis	Phase 4
Completed	`NCT00445120` - Lactobacillus Rhamnosus GG Oral Treatment Efficacy on Vernal Keratoconjunctivitis Treatment	Phase 2/Phase 3
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Completed	`NCT01211327` - Topical Cyclosporine for Vernal Keratoconjunctivitis (VKC) in Rwanda	Phase 4
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Completed	`NCT03379311` - A Study of AK002 in Patients With Atopic Keratoconjunctivitis, Vernal Keratoconjunctivitis, and Perennial Allergic Conjunctivitis	Phase 1
Completed	`NCT00426023` - Cyclosporin A Eye Drop Treatment in Vernal Keratoconjunctivitis	Phase 3
Completed	`NCT01751126` - Double-Masked Trial of NOVA22007 (1mg/mL Ciclosporin/Cyclosporine) Versus Vehicle in Pediatric Patients With Active Severe Vernal Keratoconjunctivitis	Phase 3
Recruiting	`NCT02456025` - Topical Tacrolimus in Vernal Keratoconjunctivitis	Phase 4