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Ventricular Septal Defect clinical trials

View clinical trials related to Ventricular Septal Defect.

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NCT ID: NCT06298344 Recruiting - Clinical trials for Congenital Heart Disease

The Role of Thiamine After Transcatheter Closure in Children With Left-to-Right Shunt Congenital Heart Disease

Start date: May 1, 2024
Phase: Early Phase 1
Study type: Interventional

Currently, research on the effect of thiamine administration during transcatheter closure on the structure and function of the left ventricle by examining levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in children with left to right shunt congenital heart disease has never been carried out in Indonesia, so it is necessary carried out this research. This research was carried out by administering 100 mg of thiamine once per day to patients post transcatheter closure for 28 days. The parameters assessed were MMP-9, TIMP-1, and echocardiography to assess the structure and function of the left ventricle in CHD patients with left to right shunt lesions.

NCT ID: NCT06214182 Enrolling by invitation - Clinical trials for Ventricular Septal Defect

Immune Heterogeneity Before and After Cardiopulmonary Bypass in Children

Start date: January 1, 2024
Phase:
Study type: Observational [Patient Registry]

The goal of this observational study is to learn about functional heterogeneity of immune cells before and after cardiopulmonary bypass (CPB) in children with congenital heart disease (CHD). The main question[s] it aims to answer are: - Does CPB cause immune paralysis after CHD surgery? - How does the functional heterogeneity of immune cells change before and after CPB in children undergoing CHD surgery? Participants will receive 3ml of peripheral blood before CPB, 2 hours after CPB, and 3 days after CPB, and the peripheral blood samples will be sequenced by single cell to explore the immune heterogeneity before and after CPB.

NCT ID: NCT05939713 Recruiting - Clinical trials for Ventricular Septal Defect

Cera™ VSD Occluder Post Market Clinical Follow-up

Start date: October 13, 2023
Phase:
Study type: Observational

The objective of this post-market registry is to assess the safety and performance of the Lifetech Cera™ VSD occluder in a real-world and on-label fashion.

NCT ID: NCT05688670 Recruiting - Pain, Procedural Clinical Trials

Regional Anesthesia Following Pediatric Cardiac Surgery

Start date: March 29, 2023
Phase: Phase 4
Study type: Interventional

The purpose of this study is to evaluate pain control following pediatric cardiac surgery with the use of local anesthesia via an ultrasound guided regional anesthetic technique compared with surgeon delivered wound infiltration.

NCT ID: NCT05253209 Recruiting - Clinical trials for Ventricular Septal Defect

A Study Evaluating the Efficacy and Safety of IV L-Citrulline for the Prevention of Clinical Sequelae of Acute Lung Injury Induced by Cardiopulmonary Bypass in Pediatric Patients Undergoing Surgery for Congenital Heart Defects

Start date: June 29, 2022
Phase: Phase 3
Study type: Interventional

This is a randomized, double-blind, placebo controlled, multicenter study to compare the efficacy and safety of L-citrulline versus placebo in patients undergoing surgery for congenital heart defects. Eligible patients undergoing repair of a large unrestrictive ventricular septal defect (VSD), a partial or complete atrioventricular septal defect (AVSD), or an ostium primum atrial septal defect (primum ASD) will be eligible for enrollment.

NCT ID: NCT05200910 Completed - Clinical trials for Ventricular Septal Defect

The Effect of Transcatheter VSD Closure on Children's Appetite, Hormones and Growth

Start date: July 16, 2018
Phase:
Study type: Observational

In this study; Changes in appetite, hormones and growth of ventricular septal defect patients treated with non-surgical method were evaluated.

NCT ID: NCT04859036 Completed - Clinical trials for Autonomic Nervous System Imbalance

The Effect of Transcatheter Ventricular Septal Defect Closure on Heart Rate Variability Parameters

Start date: April 1, 2016
Phase:
Study type: Observational

In this study; we evaluated the heart rate variability parameters of pediatric patients whose VSDs were closed with the transcatheter method before and after, and compared with the control group.

NCT ID: NCT04667455 Active, not recruiting - Clinical trials for Cardiovascular Diseases

Improving Care for Children With Congenital Heart Disease.

Start date: February 17, 2020
Phase: N/A
Study type: Interventional

Establish a cardiovascular biomarker profile to help screening for congenital heart disease in infants and children as well as use non-invasive cardiac imaging in combination with such profiling to better predict the need for future cardiac interventions such as open heart surgery or cardiac catheter intervention selected types of with congenital heart disease.

NCT ID: NCT04417712 Completed - Clinical trials for Ventricular Septal Defect

Lifetech KONAR MFO Post-Market Clinical Follow-Up Study

Start date: December 4, 2019
Phase:
Study type: Observational

The purpose of the study is to collect real-world data on patient outcomes and evaluate the procedural success and performance of the Lifetech KONAR-MF™ VSD Occluder for patients with ventricular septal defect (VSD).

NCT ID: NCT04017975 Active, not recruiting - Clinical trials for Ventricular Septal Defect

Optical Tissue Identification for Myocardial Architecture

OPTIMA
Start date: December 20, 2019
Phase: Phase 2
Study type: Interventional

The goal of this study is to test the hypothesis that fiberoptic confocal microscopy (FCM) imaging during repair of common congenital heart defects is a useful adjunct for avoidance of conduction abnormalities.