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Ventricular Arrhythmias clinical trials

View clinical trials related to Ventricular Arrhythmias.

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NCT ID: NCT06281977 Recruiting - Clinical trials for Ventricular Tachycardia

Study Evaluating Dexmedetomidine in the Acute Treatment of Electrical Storm

SEDATE
Start date: May 8, 2024
Phase: Phase 3
Study type: Interventional

The objective of this study is to determine if there is a meaningful benefit to using the sedative medication dexmedetomidine in the acute treatment of patients with recurrent ventricular arrhythmias, known as electrical storm. This will be a multi-centre, double-blinded, placebo-controlled, randomized trial. Patients with electrical storm will be randomized to receive 48 to 72 hours of dexmedetomidine or placebo as part of their initial treatment in an intensive care unit.

NCT ID: NCT04921501 Recruiting - Clinical trials for Ventricular Arrhythmias

Evaluation of Electrocardiographic Measurements by High Density Electrode ECG (ECG-HD)

ECG-HD
Start date: April 6, 2021
Phase: N/A
Study type: Interventional

Cardiac electrical activity is detected on the body surface with conventional electrocardiography involving 12 leads (ECG 12). A limitation of the current ECG technique is that recordings are obtained from only 6 independent precordial leads pairs ; which may miss cardiac potentials from spatially limited regions. More extensive sampling of the body surface may contribute to additional clinical information. The present study investigates the additional sensitivity of ECG using 128 body surface leads (High Density (HD) ECG) in measuring global or regional cardiac activity.

NCT ID: NCT04495712 Completed - Clinical trials for Ventricular Arrhythmias

Antiarrhythmic Effects of Spironolactone in Patients With ICDs

SPIRIT
Start date: July 28, 2004
Phase: Phase 4
Study type: Interventional

This study will test whether spironolactone, an approved drug for among other things hypertension, will reduce the risk of severe arrhythmias in patients with implanted defibrillators. Half the patients in the study will get spironolactone and half will get a placebo. Neither the patients or their providers will know if they are getting spironolactone or placebo.

NCT ID: NCT04394637 Enrolling by invitation - Clinical trials for Ventricular Arrhythmias

Ultra High Resolution CT to Assess Role of Intramyocardial Fat and Delayed Enhancement in Ventricular Arrhythmogenesis

Start date: March 4, 2021
Phase:
Study type: Observational

This research is being done to determine how well cardiac computed tomography (CT) scanning measures of fat within the heart can predict abnormal heart rhythms and how well cardiac CT can measure scar within the heart versus cardiac magnetic resonance imaging (MRI). - People who have been enrolled in PROSe-ICD (NA_00045142) and Reynolds (NA_00037404) studies may join - The procedures, tests, drugs or devices that are part of this research and will be paid for by the study

NCT ID: NCT02864771 Active, not recruiting - Heart Disease Clinical Trials

Scandinavian Multicenter Study to Advance Risk Stratification in Heart Disease- Ventricular Arrhythmias

SMASH 1
Start date: August 2016
Phase:
Study type: Observational

The purpose of this study is to identify markers of increased risk for incident ventricular arrhythmias and cardiovascular events in patients already being treated with an implantable cardioverter-defibrillator (ICD) by exploring patient history and clinical findings, biological markers, ECG markers, and echocardiographic markers.

NCT ID: NCT02772380 Completed - Tachycardia Clinical Trials

Acute Study to Collect Electrical Signals From the Heart Using a Special Lead

Start date: May 2016
Phase: N/A
Study type: Interventional

The main purpose of this clinical study is to collect electrograms from an investigational lead placed in an extravascular space, for development of a future Implantable Cardioverter Defibrillator (ICD) system.

NCT ID: NCT02699255 Completed - Atrial Fibrillation Clinical Trials

Ventricular Arrhythmias After Pulmonary Vein Isolation

Start date: October 2014
Phase:
Study type: Observational

The investigators study aimed to observe the occurrence of new premature ventricular complexes and other ventricular arrhythmias after pulmonary vein isolation.

NCT ID: NCT02275104 Completed - Clinical trials for Persistent Atrial Fibrillation

Multimodal Image Processing Software to Guide Cardiac Ablation Therapy

MIGAT
Start date: September 1, 2014
Phase: N/A
Study type: Observational

MIGAT will develop and transfer software tools to assist ablation therapy of cardiac arrhythmias. The scientific background and objectives of MIGAT differ between atrial and ventricular arrhythmias, because the knowledge on structure-function relationships and the definition of ablation targets are different. Hypothesis: The combination of body surface mapping and imaging will enable a comprehensive non-invasive assessment of cardiac arrhythmia mechanisms and localization, myocardial structural substrate, and cardiac anatomy, all of which should be of value to better define targets for ablation therapy. No software solution is currently available for multimodal data processing, fusion, and integration in 3-dimensional mapping systems to assist ablation. Because such a development requires a trans-disciplinary approach (cardiac electrophysiology, imaging, computer sciences), it is likely to emerge from an academic initiative. Objectives: MIGAT will gather resources from the Liryc Institute (L'Institut de Rythmologie et Modélisation Cardiaque), the Inria (Institut National de Recherche en Informatique et en Automatique) and the University Hospital of Bordeaux to develop a computer-based solution with high expected impact on the daily management of cardiac electrical disorders. The research program will benefit from the MUSIC (Magnetom Avanto, Siemens, Erlangen, Germany) equipment recently funded as part of the "Investissement d'Avenir" program, and combining state-of-the-art electrophysiology and magnetic resonance imaging technology. MIGAT will involve software engineers, computer science researchers, cardiologists, radiologists and clinical research personnel with the following objectives: - Development of a multimodal data processing software to assist cardiac ablation - Optimization and Validation of the software in terms of user experience - Optimization and Validation of the software in terms of clinical performance - Optimization of software quality compatible with subsequent device certification and randomized-controlled evaluation

NCT ID: NCT02227121 Terminated - Clinical trials for Ventricular Arrhythmias

Acute Defibrillation Study

Start date: February 2015
Phase: N/A
Study type: Interventional

The proposed study is designed to characterize defibrillation efficacy in humans for the potential development of a new extravascular implantable cardioverter defibrillator (ICD) system.

NCT ID: NCT01905007 Recruiting - Clinical trials for Ventricular Arrhythmias

Study of Defibrillation Testing In Patients Undergoing Initial ICD Implantation

TNT-ICD
Start date: December 2010
Phase: Phase 4
Study type: Interventional

The primary objective of this study is to compare the composite outcome of total mortality and operative complications in patients who do not undergo defibrillation testing to those who do undergo defibrillation testing at the time of initial ICD implantation.