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NCT03433105 Clinical Trial

Oxygen Uptake in Weaning of Patients From Prolonged Mechanical Ventilation

Ventilator Weaning Clinical Trial

Official title:
To Investigate the Prognostic Value of Oxygen Uptake in Weaning of Patients From Prolonged Mechanical Ventilation

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03433105
Other study ID # 201710003RINB
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 23, 2018
Est. completion date August 14, 2020

Study information
Verified date September 2019
Source National Taiwan University Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

1.Research hypothesis: during weaning patient from prolonged mechanical ventilation, if the work load caused by weaning was below the patient's AT, oxygen uptake will be constant. Otherwise, if the work load was above the patient's AT, the oxygen uptake will increase.

1. Patient: who have tracheostomy tubes and with prolonged mechanical ventilation

2. Measurement: oxygen uptake(V̇O2) and respiratory mechanics during the spontaneous breathing trials

3. Outcome: Correlation between the oxygen uptake(V̇O2) and the weaning outcome

2.Specific aims:

1. to investigate the prognostic value of oxygen uptake in weaning patients from prolonged mechanical ventilation

2. Subgroup analysis may suggest which weaning protocol potentially benefit the most for each population group (cardiovascular disease, chronic pulmonary disease, neuromuscular disease, cerebrovascular disease)

Recruitment information / eligibility
Status Completed
Enrollment 157
Est. completion date August 14, 2020
Est. primary completion date August 14, 2020
Accepts healthy volunteers No
Gender All
Age group 20 Years to 100 Years
Eligibility 1. Inclusion criteria:

Adult >20 y/o Total duration of mechanical ventilation = 10 days Received tracheostomy Defervescence Meeting the criteria of weaning phase (see supplementary protocols)

2. Exclusion criteria FiO2 >50 % Unstable hemodynamics Fever with active infection No spontaneous respiratory drive Dynamic airway collapse

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Taiwan National Taiwan University Hospital Taipei

Sponsors (1)
Lead Sponsor Collaborator
National Taiwan University Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome
Type Measure Description Time frame Safety issue
Primary Measurement of oxygen uptake (V?O2) oxygen uptake during the spontaneous breathing trial up to 12 hours during the spontaneous breathing trial
See also
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