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Clinical Trial Summary

Difficult weaning from ventilation and extubation failure are major issues in intensive care, concerning 30% and 12% of patients respectively. These can be partly explained by the lack of accuracy of spontaneous breathing trial (SBT) failure criteria to predict extubation failure. The investigators performed a pilot study to evaluate transcutaneous carbon dioxide pressure (tcPCO2) monitoring during SBTs. The results showed that the difference between maximum and initial tcPCO2 (or ΔtcPCO2) was significantly higher in the group of patients who failed SBTs according to the usual criteria. Moreover, the results suggested that ΔtcPCO2 could be an accurate and early criterion for SBT failure. The size of the study could not examine ΔtcPCO2 regarding extubation failure. Therefore, the main objective of this study is to determine if Δ tcPCO2 during SBTs is associated with extubation failure.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT02894177
Study type Interventional
Source Versailles Hospital
Contact Morisset Laure
Phone 0139239785
Email lmorisset@ch-versailles.fr
Status Recruiting
Phase N/A
Start date September 4, 2017
Completion date November 2018

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