Venous Thromboembolism Clinical Trial
Official title:
Venous Thromboembolism and Bleeding Risk in Patients With Esophageal Cancer
This study aims to assess the 6- and 12-month venous thromboembolism (VTE) and bleeding incidence from the start of cancer diagnosis in a retrospective cohort of patients with esophageal cancer. Additionally, the predictive value of the Khorana score and several other VTE and bleeding prediction scores and risk factors will be evaluated.
Patients with cancer are at high risk of venous thromboembolism (VTE), including deep-vein
thrombosis and pulmonary embolism. For cancer patients receiving chemotherapy the incidence
of VTE is even higher.
Several predictive models were previously developed to identify and justify
thromboprophylaxis for cancer patietns who are at highest risk of VTE, like the Khorana and
PROTECHT score. The Khorana score is a risk-stratification tool to select patients at high
risk of VTE for thromboprophylaxis. The PROTECHT score takes cisplatin-based chemotherapy
into account in addition of the Khorana score.
Thereby, the incidence of bleeding and VTE in patients with esophageal cancer is not clear.
This study aims to assess the 6- and 12-month venous thromboembolism (VTE) and bleeding
incidence from the start of cancer diagnosis in a retrospective cohort of patients with
esophageal cancer. Additionally, the predictive value of the Khorana score and several other
VTE and bleeding prediction scores and risk factors will be evaluated.
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