Venous Sinus Thrombosis, Cranial Clinical Trial
Official title:
Imaging Research on Anatomical Variation of Cerebral Venous Sinus in Healthy Individuals
NCT number | NCT05413837 |
Other study ID # | CVSAV-HI |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | July 6, 2022 |
Est. completion date | August 31, 2023 |
The anatomical characteristics of veins and venous sinus result in great differences between cerebral venous system diseases and cerebral artery diseases in etiology, pathophysiology and clinical features.Therefore, understanding the anatomy and variation of normal venous sinuses is essential to identify the intracranial venous lesions.
Status | Recruiting |
Enrollment | 40 |
Est. completion date | August 31, 2023 |
Est. primary completion date | August 31, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 35 Years |
Eligibility | Inclusion Criteria: 1. Age 18 - 35 years old. 2. Confirmed no intracranial diseases, congenital abnormalities such as intracranial hematoma, tumor, vascular malformation, hydrocephalus, etc. 3. Voluntarily signed informed consent. Exclusion Criteria: 1. Any clinical history, including hypertension, diabetes, coronary heart disease, hematologic and rheumatic immune system diseases,cervical spondylosis, anxiety, depression, insomnia, etc. 2. Internal jugular venous outflow disturbance : MRV from extracranial to aortic arch demonstrates variation or stenosis of the internal jugular vein, vertebral plexus, brachiocephalic vein, and superior vena cava. 3. Any history of craniocerebral trauma or surgery that affected the existence and running of veins.Unhealthy habits such as smoking, heavy drinking, etc. 4. Women who are pregnant or in preparation for pregnancy or lactation. 5. Other conditions that the researchers considered might affect the trial and inappropriate for inclusion. |
Country | Name | City | State |
---|---|---|---|
China | Xuanwu hospital;Capital Medical University | Beijin | XI Cheng District |
Lead Sponsor | Collaborator |
---|---|
Capital Medical University |
China,
Cheng Y, Li WA, Fan X, Li X, Chen J, Wu Y, Meng R, Ji X. Normal anatomy and variations in the confluence of sinuses using digital subtraction angiography. Neurol Res. 2017 Jun;39(6):509-515. doi: 10.1080/01616412.2017.1323383. Epub 2017 May 11. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The anotomy and variation of venous sinus in Chinese healthy individuals | According to the connection types of superior sagittal sinus and transverse sinus at the the torcular Herophili assessed with contrast-enhanced MR venography and phase-contrast MR venography, describe the anatomical classification of venous sinus based on the anatomical descriptions of Osborn and describe the anatomical variations that are not included in the existing classification. Calculating the proportion of each type. | On the day of examination | |
Secondary | The diameters of venous sinus and small veins in Chinese healthy individuals | Measuring the diameters of venous sinus and small veins assessed with contrast-enhanced MR venography | On the day of examination | |
Secondary | Serum biomarkers in Chinese healthy individuals | The level of biomarkers are detected using Elisa or omics analysis | On the day of examination |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03281590 -
Stroke and Cerebrovascular Diseases Registry
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