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Assessment of Midodrine in the Prevention of Vasovagal Syncope: The Prevention of Syncope Trial IV — POST 4  

Vasovagal Syncope Clinical Trial

Official title:
Assessment of Midodrine in the Prevention of Vasovagal Syncope: The Prevention of Syncope Trial IV (Post 4)

Clinical Trial Summary

About 20% of adults faint recurrently. These patients are often highly symptomatic, have problems with employment and driving and have reduced quality of life. There are no therapies that have withstood the test of adequately designed and conducted randomized clinical trials. Midodrine is a prodrug whose metabolite is an alpha-1 adrenergic agonist that increases venous return to the heart and raises blood pressure. There is considerable lower level evidence that it might prevent vasovagal syncope. The investigators will test the hypothesis that Midodrine prevents recurrences of syncope in patients with moderate to severe vasovagal syncope.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01456481
Study type Interventional
Source University of Calgary
Contact
Status Active, not recruiting
Phase Phase 4
Start date November 2011
Completion date December 31, 2023
View Details
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