Vasospastic Angina Clinical Trial
Official title:
Vericiguat in Vasospastic Angina
Vasospastic angina is increasingly recognized as an important contributor to anginal symptoms in patients with non-obstructive coronary artery disease (ANOCA). Endothelial dysfunction and smooth muscle cell dysfunction are considered elementary in the development of vasospastic angina. As one of many functions, the vascular endothelium regulates local vascular tone, mainly through the vasodilatory effect of endothelium-derived nitric oxide (NO). Vericiguat is a soluble guanylate cyclase (sGC) stimulator and thereby acts directly on the NO signalling pathway from the endothelium towards the vascular smooth muscle cells. As such, Vericiguat potentially has an beneficial therapeutic effect in patients with vasospastic angina.The VIVA study aims to demonstrate the effect of Vericiguat on endothelial function and microvascular vasodilator responses, as well as its tolerability and safety in patients with vasospastic angina as the pathophysiological substrate of ANOCA.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04827498 -
Myocardial Ischemia Without Obstructive Coronary Stenoses
|
||
| Completed |
NCT02087007 -
A Therapeutic Confirmatory Study to Evaluate the Efficacy and Safety of Cilostazol in Subjects With Vasospastic Angina
|
Phase 3 | |
| Recruiting |
NCT05294887 -
Randomized Trial to Examine a Differential Therapeutic Response in Symptomatic Patients With Non-obstructive Coronary Artery Disease
|
Phase 4 | |
| Recruiting |
NCT06401291 -
Transcutaneous Electrical Nerve Stimulation in Patients With Angina and Non-Obstructive Coronary Arteries
|
N/A | |
| Recruiting |
NCT05313919 -
Coronary Microcirculatory Disease and Inflammation in Patients With Chronic Coronary Syndrome and no Significant Coronary Artery Stenosis
|
||
| Not yet recruiting |
NCT06424834 -
Efficacy of Targeted Medical Therapy in Angina and Nonobstructive Coronary Arteries
|
Phase 2/Phase 3 | |
| Recruiting |
NCT05282511 -
A Multi-Omics Study of Vasospastic Angina
|
||
| Recruiting |
NCT04674449 -
iCorMicA - Stratified Medicine in Angina
|
N/A | |
| Completed |
NCT02094469 -
Safety and Efficacy Study of Cilostazol to Treat Vasospastic Angina
|
Phase 3 | |
| Recruiting |
NCT02180971 -
Multidetector Coronary CT In Vasospastic Angina
|
N/A | |
| Completed |
NCT00601302 -
Bioequivalency Study of Amlodipine Tablets Under Fed Conditions
|
N/A | |
| Completed |
NCT00602017 -
Bioequivalency Study of Amlodipine Tablets Under Fasting Conditions
|
N/A |