Vasodilation Clinical Trial
Official title:
Investigation of Endothelium-dependent Vasodilation in Human Gingiva Depending on Serum Estrogen Level
Verified date | June 2024 |
Source | Semmelweis University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The first aim of this study is to create a cumulative dose-response curve for acetylcholine in men (low serum estrogen levels) to determine the lowest concentration with which we can induce a maximal vasodilation effect on the human gingiva. Furthermore, the second aim of this study is the characterization of the age-dependent effect of sex hormones on gingival blood flow, as well as of the gender differences by applying this concentration to premenopausal men and women with low and high estrogen levels, as well as to postmenopausal subjects.
Status | Active, not recruiting |
Enrollment | 80 |
Est. completion date | December 31, 2025 |
Est. primary completion date | December 31, 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 90 Years |
Eligibility | Inclusion Criteria: - healthy systemic and periodontal conditions Exclusion Criteria: - systemic disease and medication - periodontal disease - smoking |
Country | Name | City | State |
---|---|---|---|
Hungary | Department for Restorative Dentistry and Endodontics, Semmelweis University | Budapest |
Lead Sponsor | Collaborator |
---|---|
Semmelweis University |
Hungary,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | 1. Blood flow change after applying the test solution | The change in blood flow will be measured after applying the test solution | 19 minutes |
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