Vasodilation Clinical Trial
Official title:
Sex Differences in Sympathetic Vascular Reactivity at High Altitude
Verified date | March 2023 |
Source | University of Alberta |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This study aims to investigate sex differences in blood pressure control associated with exposure to acute hypoxia (low oxygen), and short term acclimatization to hypoxia at high altitude.
Status | Completed |
Enrollment | 17 |
Est. completion date | February 5, 2023 |
Est. primary completion date | February 5, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 45 Years |
Eligibility | Inclusion Criteria: - Between ages of 18-50 - No medical history of cardiovascular, respiratory, nervous system, or metabolic disease - Females must be pre-menopausal Exclusion Criteria: - Any known cardiovascular, respiratory, nervous system, or metabolic disease (however, participants with controlled arterial hypertension will not be excluded) - Having travelled above 2,000m within 1 month of testing at low and high altitude - Females who are pregnant, confirmed by a pregnancy test - Females who are post-menopausal - Participants that are classified as obese (body mass index > 30kg·m²) - Participants who are current daily smokers - Those with a known allergy to sulfites - Participants taking monoamine oxidase (MAO) inhibitors or tricyclic antidepressants or other medications that have contraindications with the study drugs - Participants who are still within the washout period from participating in other studies involving drugs. |
Country | Name | City | State |
---|---|---|---|
Canada | University of Alberta | Edmonton | Alberta |
Canada | University of British Columbia - Okanagan | Kelowna | British Columbia |
Lead Sponsor | Collaborator |
---|---|
University of Alberta |
Canada,
Hart EC, Charkoudian N, Wallin BG, Curry TB, Eisenach JH, Joyner MJ. Sex differences in sympathetic neural-hemodynamic balance: implications for human blood pressure regulation. Hypertension. 2009 Mar;53(3):571-6. doi: 10.1161/HYPERTENSIONAHA.108.126391. Epub 2009 Jan 26. — View Citation
Mazzeo RS, Child A, Butterfield GE, Mawson JT, Zamudio S, Moore LG. Catecholamine response during 12 days of high-altitude exposure (4, 300 m) in women. J Appl Physiol (1985). 1998 Apr;84(4):1151-7. doi: 10.1152/jappl.1998.84.4.1151. — View Citation
Purdy GM, James MA, Rees JL, Ondrus P, Keess JL, Day TA, Steinback CD. Spleen reactivity during incremental ascent to altitude. J Appl Physiol (1985). 2019 Jan 1;126(1):152-159. doi: 10.1152/japplphysiol.00753.2018. Epub 2018 Nov 21. — View Citation
Usselman CW, Gimon TI, Nielson CA, Luchyshyn TA, Coverdale NS, Van Uum SH, Shoemaker JK. Menstrual cycle and sex effects on sympathetic responses to acute chemoreflex stress. Am J Physiol Heart Circ Physiol. 2015 Mar 15;308(6):H664-71. doi: 10.1152/ajpheart.00345.2014. Epub 2014 Dec 19. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in systolic, diastolic, and mean arterial blood pressure | modified oxford | 3 minutes | |
Primary | Change in arterial blood flow | phenylephrine and norepinephrine sensitivity | 1 hour 30 minutes | |
Primary | Change in vascular conductance | exercise and metaboreflex reactivity | 20 minutes | |
Primary | Cold pressor test | sympathetic reactivity | 3 minutes | |
Primary | Propranolol | changes in vascular conductance | 2 hours | |
Primary | Phentolamine | changes in vascular conductance | 1 hour |
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