Vasodilation Clinical Trial
— CarMAOfficial title:
The Impact of Carbon Monoxide and Altitude on Vascular Function
NCT number | NCT04928183 |
Other study ID # | Pro00096251 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | June 10, 2021 |
Est. completion date | May 18, 2022 |
Verified date | June 2021 |
Source | University of Alberta |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The CarMA (Carbon Monoxide and Altitude) Study aims to observe the vascular effects of carbon monoxide exposure at low and high altitudes.
Status | Completed |
Enrollment | 19 |
Est. completion date | May 18, 2022 |
Est. primary completion date | August 1, 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 50 Years |
Eligibility | Inclusion Criteria: - Between the ages of 18-50 years - No medical history of cardiovascular, respiratory, nervous system, or metabolic disease. - Women must be pre-menopausal. Exclusion Criteria: - Participants with any known cardiovascular, respiratory, nervous system, or metabolic disease. - Having travelled above 2,000m within 1 month of testing at low and high altitude. - Women who are pregnant, confirmed by a pregnancy test. - Women who are post-menopausal. - Participants that are classified as obese (body mass index > 30 kg/m2). - Participants who are current daily smokers. - Participants that are currently taking monoamine (MAO) inhibitors, or tricyclic antidepressants. |
Country | Name | City | State |
---|---|---|---|
Canada | University of Alberta | Edmonton | Alberta |
Lead Sponsor | Collaborator |
---|---|
University of Alberta |
Canada,
Basnyat B. High altitude pilgrimage medicine. High Alt Med Biol. 2014 Dec;15(4):434-9. doi: 10.1089/ham.2014.1088. Review. — View Citation
Choi BG, Lee J, Kim SW, Lee MW, Baek MJ, Ryu YG, Choi SY, Byun JK, Mashaly A, Park Y, Jang WY, Kim W, Choi JY, Park EJ, Na JO, Choi CU, Lim HE, Kim EJ, Park CG, Seo HS, Oh DJ, Rha SW. The association of chronic air pollutants with coronary artery spasm, vasospastic angina, and endothelial dysfunction. Coron Artery Dis. 2018 Jun;29(4):336-343. doi: 10.1097/MCA.0000000000000603. — View Citation
Rezk-Hanna M, Mosenifar Z, Benowitz NL, Rader F, Rashid M, Davoren K, Moy NB, Doering L, Robbins W, Sarna L, Li N, Chang LC, Elashoff RM, Victor RG. High Carbon Monoxide Levels from Charcoal Combustion Mask Acute Endothelial Dysfunction Induced by Hookah (Waterpipe) Smoking in Young Adults. Circulation. 2019 May 7;139(19):2215-2224. doi: 10.1161/CIRCULATIONAHA.118.037375. — View Citation
Tymko MM, Tremblay JC, Bailey DM, Green DJ, Ainslie PN. The impact of hypoxaemia on vascular function in lowlanders and high altitude indigenous populations. J Physiol. 2019 Dec;597(24):5759-5776. doi: 10.1113/JP277191. Epub 2019 Nov 28. Review. — View Citation
Weber LP, Al-Dissi A, Marit JS, German TN, Terletski SD. Role of carbon monoxide in impaired endothelial function mediated by acute second-hand tobacco, incense, and candle smoke exposures. Environ Toxicol Pharmacol. 2011 May;31(3):453-9. doi: 10.1016/j.etap.2011.02.008. Epub 2011 Feb 26. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in brachial artery diameter (assessed via ultrasound) following release of arterial occlusion | Change in brachial artery diameter (assessed via ultrasound) following release of arterial occlusion | 15 minutes | |
Primary | Blood flow within the brachial artery during rhythmic handgrip exercise. | Blood flow within the brachial artery during rhythmic handgrip exercise. | 15 minutes | |
Primary | Change in brachial artery conductance following an infusion of phenylephrine | Change in brachial artery conductance following an infusion of phenylephrine | 5 min |
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