Vasodilation Clinical Trial
Official title:
The Impact of Carbon Monoxide and Altitude on Vascular Function
The CarMA (Carbon Monoxide and Altitude) Study aims to observe the vascular effects of carbon monoxide exposure at low and high altitudes.
Each year, millions of people make journeys from low altitude regions to high altitude for recreation, travel, and religious pilgrimage. Carbon monoxide (CO) is commonly associated with cigarette smoke, exhaust fumes, and is viewed as a life-threatening toxic gas. Exposure to CO occurs during travel to and during activities common in high-altitude travel and pilgrimage including vehicle fumes, incense, and second-hand smoke exposure. High altitude exposure and CO exposure have been observed independently to have complex and opposing effects on vascular endothelial function. Observation of these stimuli together in a controlled environment may allow for further understanding of the underlying mechanisms of vascular physiology and adaptations to both high-altitude and CO exposure. The CarMA (Carbon Monoxide and Altitude) Study aims to observe the vascular effects of carbon monoxide exposure at low and high altitudes. Recently, other studies have showed a significant improvement in flow mediated dilation (FMD) with acute exposure to low levels of CO To date, no research has been presented concerning the effect of CO on vascular function at altitude. The present study aims to observe the effect of acute carbon monoxide exposure on 1) flow mediated dilation, 2) conduit artery flow in exercise induced reactive hyperemia at sea level and at altitude, and 3) the effect of CO on vascular function in a high altitude dwelling (sherpa) population. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03680638 -
The Effect of Antioxidants on Skin Blood Flow During Local Heating
|
Phase 1 | |
| Active, not recruiting |
NCT06454084 -
Investigation of Endothelium-dependent Vasodilation in Human Gingiva
|
N/A | |
| Recruiting |
NCT05997732 -
Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences
|
Phase 4 | |
| Recruiting |
NCT06117007 -
Effects of Betalains on Cardiovascular Health and Quality of Life
|
N/A | |
| Completed |
NCT03659864 -
The Role of Eicosanoids in the Cardiovascular Actions of Inhaled Nanoparticles
|
N/A | |
| Completed |
NCT03459027 -
Nitrate Supplementation and Muscle Blood Flow
|
N/A | |
| Recruiting |
NCT04255160 -
Impact of Estradiol on Endothelial Function in Peri-Menopausal Women
|
Phase 4 | |
| Recruiting |
NCT05522075 -
Reducing Blood Pressure in Mid-life Adult Binge Drinkers
|
N/A | |
| Completed |
NCT00184886 -
The Influence of Methotrexate on the Metabolism and Vascular Effects of Adenosine in Humans
|
N/A | |
| Completed |
NCT02292342 -
An Investigation of the Dose-dependent Vascualr Effects of (-)-Epicatechin in Healthy Men
|
Phase 0 | |
| Completed |
NCT02095873 -
Healthy Aging Through Functional Food
|
Phase 1/Phase 2 | |
| Completed |
NCT00901745 -
Interaction of Apelin and Angiotensin in the Human Forearm Circulation
|
N/A | |
| Not yet recruiting |
NCT06290713 -
Vasodilator and Exercise Study for DMD (VASO-REx)
|
Phase 2 | |
| Completed |
NCT02265107 -
Effects of Exercise Training on Vascular Endothelial Function of Patients Submitted to Coronary Artery Bypass Graft
|
N/A | |
| Recruiting |
NCT05219799 -
Sex Disparities in Hypoxic Vasodilation and Impact of Obesity
|
Early Phase 1 | |
| Completed |
NCT03622060 -
Intraarterial Nitroglycerin Versus Nicardipine and Radial Artery Occlusion
|
Phase 3 | |
| Not yet recruiting |
NCT06417177 -
Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia
|
Early Phase 1 | |
| Completed |
NCT01618071 -
Vascular Effects of Triglyceride-rich Lipoproteins
|
N/A | |
| Completed |
NCT03190304 -
The Effect of Neprilysin (LCZ696) on Exercise Tolerance in Patients With Heart Failure
|
Phase 4 | |
| Suspended |
NCT04001647 -
Targeting ER Stress in Vascular Dysfunction
|
Early Phase 1 |