Clinical Trial Details
— Status: Not yet recruiting
Administrative data
| NCT number |
NCT05889897 |
| Other study ID # |
pediatric vascular thrombosis |
| Secondary ID |
|
| Status |
Not yet recruiting |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
August 1, 2023 |
| Est. completion date |
July 1, 2024 |
Study information
| Verified date |
July 2023 |
| Source |
Assiut University |
| Contact |
Doaa sayed |
| Phone |
01064884771 |
| Email |
nananony551996[@]gmail.com |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
This study is aimed to identify the prevalence, risk factors and outcomes of children with
either venous or arterial thromboembolism admitted to children hospital Assiut University
aiming at early detection and avoidance of catastrophic complications .
Description:
Thrombosis is a blood clot that develops within veins or sometimes arteries in the body.
Occur most commonly in the inferior and superior vena cava, their major tributaries, the deep
veins of the extremities, the splanchnic veins, as well as the cerebral venous sinuses.
The incidence of venous thromboembolism (VTE) increases with age. In the pediatric population
(0-18 years) the incidence is approximately 0.7-2.1 cases per 100,000 children,1-3 while in
the adult population the incidence is 100-150 per 100,000.4
Risk factors include the presence of central venous lines, trauma, major surgery followed by
bedrest, immobilization, infection (cellulitis, osteomyelitis, phlebitis), cancer
chemotherapy, inflammatory bowel disease, nephrotic syndrome, obesity, dehydration, and total
parenteral nutrition.
Patients with vascular thromboembolism present with various symptoms depending on site of
thrombosis , symptoms include swelling, redness, pain , low-grade fever In cases that develop
pulmonary embolism they experience chest pain and shortness of breath that begin suddenly
Diagnosis of vascular thromboembolism include combination of signs and symptoms together with
laboratory investigations that include routine lab investigations, D-dimer , protein s ,
protein C and antithrombin lll also imaging studies as Doppler US , MSCT with angiography and
MRV
Vascular thrombosis mainly treated with anticoagulant therapy with subcutaneous injection of
low molecular weight heparin These medications prevent the clot from growing and decrease the
risk of its breaking apart and causing further complications Other treatments may include
wearing compression stockings and applying warm packs to improve blood flow and pain caused
by the clot
