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Effect of Changing Physiological Conditions on Myogenic Oscillations: Pilot Study

Vascular Diseases Clinical Trial

Official title:
A Pilot Study to Evaluate the Effect of Changing Physiological Conditions on the Amplitude and/or Frequency of Myogenic Oscillations

Clinical Trial Summary

Spontaneous myogenic oscillations will be studied under general anesthesia using finger photoplethysmography. This pilot study will explore potential physiological conditions that will effect the amplitude and/or frequency of myogenic oscillations.

Clinical Trial Description

This is a single center, nonrandomized, nonblinded, interventional clinical pilot research study that plans to enroll 40 patients. Study will be conducted while subjects are under general anesthesia. Myogenic oscillations will be measured using finger photoplethysmography. Changes in the amplitude and/or frequency of these oscillations will be analyzed in response to the interventions. Arterial blood pressure will be recorded to verify the efficacy of the interventions. Six different interventions that will either lower or increase blood pressure will be applied to the subjects. Each subject will receive 1 or 2 of the six interventions. Each of the 6 interventions will be applied to 8 subject. The interventions that the subject will not be randomized. They will be determined by the subjects blood pressure immediately before the intervention to guarantee that the blood pressure manipulations are within a safe range. Data will be analyzed offline using Matlab. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03719001
Study type Interventional
Source University of California, San Francisco
Contact
Status Completed
Phase Early Phase 1
Start date October 23, 2018
Completion date June 15, 2022
View Details
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