Vascular Aneurysm Clinical Trial
Official title:
miRNA in Patients With Thoracic, Abdominal and Intracranial Aneurysms
To assess the expression of miRNA in patients with TAA, AAA in aneurysmatic tissue and to compare this expression with the healthy tissue in the same patient. In the same cohort, to asses the presence of miRNA in plasma and to compare with the control group. Over the period of three years,to follow subjects in order to assess if the presence of certain miRNAs speeds up or slows down the progression of disease. In patients with intracranial aneurysms to detect miRNA in plasma especially in patients with familial occurrence.
MicroRNAs constitute a recently discovered class of non-coding RNAs that play key roles in the regulation of gene expression. Acting at the post-transcriptional level, MicroRNAs have been shown to be involved in a wide range of biological processes such as cell cycle control, apoptosis and several developmental and physiological processes including stem cell differentiation, hematopoiesis, hypoxia, cardiac and skeletal muscle development. In addition to their important roles in healthy individuals, microRNAs have also been implicated in a number of diseases including a broad range of cancers, cardiovascular and heart disease. Their different expression in aortic tissue in patients with aortic abdominal aneurysm and their association with the progression of the disease were confirmed. They represent the potential target for the treatment of the disease. MiRNA act as biomarkers showing the potential risk of the presence of TAA, AAA and intracranial aneurysm, for the prediction of TAA and AAA progression and for the discovery of new treatment possibilities. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04630535 -
OSA as a Remote Ischemic Preconditioning in Vascular Surgery
|
||
| Recruiting |
NCT04381507 -
A Study in Patients With a Descending TAA or PAU Treated With the E-nya Thoracic Stent Graft System
|
||
| Recruiting |
NCT04765176 -
A PMCF Study in Patients With Infrarenal Aortic Aneurysm Treated With the E-tegra Stent Graft System
|
||
| Completed |
NCT05350358 -
LeMaitre® CARDIAL Dialine II Post Market Study
|
||
| Recruiting |
NCT04383145 -
A Study in Patients With Thoracoabdominal Aortic Aneurysm Treated With the E-nside TAAA Multibranch Stent Graft System
|
||
| Recruiting |
NCT03606083 -
Registry in Patients With Aorto-iliac or Iliac Aneurysms
|
||
| Recruiting |
NCT05721001 -
French Registry Conducted on E-vita OPEN NEO
|
||
| Recruiting |
NCT05586503 -
EASYII - E-tegra Stent Graft System - Imaging Cohort
|
N/A |